ENSMUSG00000020828


Mus musculus

Features
Gene ID: ENSMUSG00000020828
  
Biological name :Pld2
  
Synonyms : P97813 / Phospholipase D2 / Pld2
  
Possible biological names infered from orthology : O14939
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70540064
Gene end: 70558110
  
Corresponding Affymetrix probe sets: 10377859 (MoGene1.0st)   1417237_at (Mouse Genome 430 2.0 Array)   1457252_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104197
Ensembl peptide - ENSMUSP00000018429
Ensembl peptide - ENSMUSP00000104196
Ensembl peptide - ENSMUSP00000136566
Ensembl peptide - ENSMUSP00000137247
NCBI entrez gene - 18806     See in Manteia.
MGI - MGI:892877
RefSeq - XM_017314339
RefSeq - NM_001302475
RefSeq - NM_001302476
RefSeq - NM_008876
RefSeq - XM_011248794
RefSeq - XM_011248795
RefSeq - XM_011248796
RefSeq - XM_011248797
RefSeq Peptide - NP_001289404
RefSeq Peptide - NP_001289405
RefSeq Peptide - NP_032902
swissprot - Q6NV49
swissprot - P97813
swissprot - J3QK47
swissprot - Q80ZW1
swissprot - Q5SXG5
swissprot - J3QN26
Ensembl - ENSMUSG00000020828
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pld2ENSDARG00000034262Danio rerio
 PLD2ENSG00000129219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pld1 / phospholipase D1 / Q13393*ENSMUSG0000002769555


Protein motifs (from Interpro)
Interpro ID Name
 IPR001683  Phox homologous domain
 IPR001736  Phospholipase D/Transphosphatidylase
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015679  Phospholipase D family
 IPR016555  Phospholipase D, eukaryotic type
 IPR025202  Phospholipase D-like domain
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002031 G-protein coupled receptor internalization IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process IEA
 biological_processGO:0006898 receptor-mediated endocytosis IDA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0036465 synaptic vesicle recycling IBA
 biological_processGO:0048017 inositol lipid-mediated signaling IEA
 biological_processGO:0048870 cell motility IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031526 brush border membrane IDA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004630 phospholipase D activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Role of phospholipids in phagocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: BsnGt(OST486029)Lex/BsnGt(OST486029)Lex
Genetic Background: Not Specified

Allelic Composition: Pld2tm1.1Gdp/Pld2tm1.1Gdp,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pld1tm1.1Mafr/Pld1tm1.1Mafr,Pld2tm1Yaka/Pld2tm1Yaka
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: BsnGt(OST486029)Lex/BsnGt(OST486029)Lex
Genetic Background: Not Specified

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kmt2dGt(RRT024)Byg/Kmt2dGt(RRT024)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld2tm1.1Gdp/Pld2tm1.1Gdp,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pld2tm1.1Gdp/Pld2+,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Pld2tm1.1Gdp/Pld2tm1.1Gdp,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0020408 altered susceptibility to induced thrombosis "any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]
Show

Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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