ENSMUSG00000027695


Mus musculus

Features
Gene ID: ENSMUSG00000027695
  
Biological name :Pld1
  
Synonyms : phospholipase D1 / Pld1
  
Possible biological names infered from orthology : Q13393
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 27938695
Gene end: 28133362
  
Corresponding Affymetrix probe sets: 10491106 (MoGene1.0st)   1425739_at (Mouse Genome 430 2.0 Array)   1437112_at (Mouse Genome 430 2.0 Array)   1437113_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121318
Ensembl peptide - ENSMUSP00000120273
Ensembl peptide - ENSMUSP00000121569
Ensembl peptide - ENSMUSP00000064694
Ensembl peptide - ENSMUSP00000113810
Ensembl peptide - ENSMUSP00000118727
NCBI entrez gene - 18805     See in Manteia.
MGI - MGI:109585
RefSeq - XM_017319491
RefSeq - NM_001164056
RefSeq - NM_008875
RefSeq - XM_006535414
RefSeq - XM_017319489
RefSeq - XM_017319490
RefSeq Peptide - NP_001157528
RefSeq Peptide - NP_032901
swissprot - F6QJR6
swissprot - F6WKY8
swissprot - D6RH77
swissprot - Q6NVF2
swissprot - D3Z2V2
Ensembl - ENSMUSG00000027695
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pld1aENSDARG00000056228Danio rerio
 pld1bENSDARG00000057125Danio rerio
 ENSGALG00000009252Gallus gallus
 PLD1ENSG00000075651Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pld2 / P97813 / Phospholipase D2 / O14939*ENSMUSG0000002082850


Protein motifs (from Interpro)
Interpro ID Name
 IPR001683  Phox homologous domain
 IPR001736  Phospholipase D/Transphosphatidylase
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015679  Phospholipase D family
 IPR016555  Phospholipase D, eukaryotic type
 IPR025202  Phospholipase D-like domain
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006654 phosphatidic acid biosynthetic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032534 regulation of microvillus assembly IEA
 biological_processGO:0048017 inositol lipid-mediated signaling IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004630 phospholipase D activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Role of phospholipids in phagocytosis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pld1tm1.1Mafr/Pld1tm1.1Mafr,Pld2tm1Yaka/Pld2tm1Yaka
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2dGt(RRT024)Byg/Kmt2dGt(RRT024)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2dGt(RRT024)Byg/Kmt2dGt(RRT024)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkrptm1Scbr/Fkrptm1Scbr,Sox1tm1(cre)Take/Sox1+,Tg(CAG-LARGE)126Fmu/0
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pitx2tm1b(EUCOMM)Wtsi/Pitx2+
Genetic Background: C57BL/6N-Pitx2tm1b(EUCOMM)Wtsi/H

 MP:0020408 altered susceptibility to induced thrombosis "any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]
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Allelic Composition: Pld1tm3Mafr/Pld1tm3Mafr,Pld2tm1(KOMP)Vlcg/Pld2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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