ENSMUSG00000020850


Mus musculus

Features
Gene ID: ENSMUSG00000020850
  
Biological name :Prpf8
  
Synonyms : Pre-mRNA-processing-splicing factor 8 / Prpf8 / Q99PV0
  
Possible biological names infered from orthology : pre-mRNA processing factor 8 / Q6P2Q9
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 75486816
Gene end: 75509449
  
Corresponding Affymetrix probe sets: 10378579 (MoGene1.0st)   1422453_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099568
Ensembl peptide - ENSMUSP00000115635
Ensembl peptide - ENSMUSP00000018449
NCBI entrez gene - 192159     See in Manteia.
MGI - MGI:2179381
RefSeq - NM_138659
RefSeq Peptide - NP_619600
swissprot - B7ZC27
swissprot - Q99PV0
Ensembl - ENSMUSG00000020850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prpf8ENSDARG00000026180Danio rerio
 PRPF8ENSGALG00000002943Gallus gallus
 PRPF8ENSG00000174231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR012337  Ribonuclease H-like superfamily
 IPR012591  PRO8NT domain
 IPR012592  PROCN domain
 IPR012984  PROCT domain
 IPR019580  Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
 IPR019581  Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
 IPR019582  RNA recognition motif, spliceosomal PrP8
 IPR021983  PRP8 domain IV core
 IPR027652  Pre-mRNA-processing-splicing factor 8
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly IBA
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005682 U5 snRNP ISO
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030532 small nuclear ribonucleoprotein complex IEA
 cellular_componentGO:0046540 U4/U6 x U5 tri-snRNP complex ISO
 cellular_componentGO:0071007 U2-type catalytic step 2 spliceosome IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IBA
 molecular_functionGO:0000386 second spliceosomal transesterification activity IBA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017070 U6 snRNA binding IBA
 molecular_functionGO:0030619 U1 snRNA binding IBA
 molecular_functionGO:0030620 U2 snRNA binding IBA
 molecular_functionGO:0030623 U5 snRNA binding IBA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding ISO
 molecular_functionGO:0097157 pre-mRNA intronic binding IBA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Prpf3tm1.1Eap/Prpf3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Prpf8tm1.1Eap/Prpf8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prpf3tm1.1Eap/Prpf3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Prpf8tm1.1Eap/Prpf8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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