Manteia - Molecule gene

ENSMUSG00000021003

Mus musculus

Features

Gene ID:	ENSMUSG00000021003

Biological name :	Galc

Synonyms :	Galactocerebrosidase / Galc / P54818

Possible biological names infered from orthology :	galactosylceramidase / P54803

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	E
Gene start:	98202294
Gene end:	98259459

Corresponding Affymetrix probe sets:	10401968 (MoGene1.0st) 1420547_at (Mouse Genome 430 2.0 Array) 1449900_at (Mouse Genome 430 2.0 Array) 1452907_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000021390 Ensembl peptide - ENSMUSP00000152540 NCBI entrez gene - 14420 See in Manteia. MGI - MGI:95636 RefSeq - XM_017314960 RefSeq - NM_008079 RefSeq - XM_006515472 RefSeq Peptide - NP_032105 swissprot - P54818 swissprot - A0A1Y7VM63 Ensembl - ENSMUSG00000021003

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
galca	ENSDARG00000037064	Danio rerio
galcb	ENSDARG00000016474	Danio rerio
GALC	ENSGALG00000010593	Gallus gallus
GALC	ENSG00000054983	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001286	Glycoside hydrolase, family 59
IPR017853	Glycoside hydrolase superfamily
IPR035394	Glycosyl hydrolase family 59, central domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006665	sphingolipid metabolic process	IEA
biological_process	GO:0006683	galactosylceramide catabolic process	IEA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0016042	lipid catabolic process	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005764	lysosome	TAS
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004336	galactosylceramidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA

Pathways (from Reactome)

Pathway description

Glycosphingolipid metabolism

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0000125	absent incisors	"missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000133	abnormal long bone metaphysis morphology	"malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0000136	abnormal microglial cell morphology	"anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0000440	domed skull		Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Nod2^tm1Flv/Nod2^tm1Flv Genetic Background: involves: 129S1/Sv
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh Genetic Background: B6.129-Gpx1^tm1Ysh Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J Allelic Composition: Galc^twi-4J/Galc^twi-4J Genetic Background: involves: C57BL/6J Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J Allelic Composition: Galc^twi-2J/Galc^twi-2J Genetic Background: B10.A-H2ⁱ⁵/(R5)SgSn Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi-3J Genetic Background: involves: C57BL/6J * CE/J
MP:0000746	weakness	"state of being infirm or less strong than littermates" [J:45400]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J
MP:0000748	progressive muscle weakness	"increasing loss of strength over time" [MGI:CLS, J:67994]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CE/J
MP:0000754	partial paralysis	"partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh Genetic Background: B6.129-Gpx1^tm1Ysh Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000841	abnormal hindbrain morphology	"malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0000846	abnormal medulla oblongata	"anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0000848	abnormal pons	"malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh Genetic Background: B6.129-Gpx1^tm1Ysh Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: CE/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000954	reduced oligodendrocyte progenitor number	"fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J
MP:0000958	peripheral nervous system degeneration	"a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^M1Btlr/Galc^M1Btlr Genetic Background: C57BL/6J-Galc^M1Btlr Allelic Composition: Galc^M1Btlr/Galc⁺ Genetic Background: C57BL/6J-Galc^M1Btlr
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cd79b^tm3Mnz/Cd79b^tm3Mnz Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi-3J Genetic Background: involves: C57BL/6J * CE/J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi,Hpgds^tm1Urad/Hpgds^tm1Urad Genetic Background: B6.Cg-Hpgds^tm1Urad Galc^twi Allelic Composition: Galc^twi/Galc^twi,Ptgdr^tm1Sna/Ptgdr^tm1Sna Genetic Background: B6.Cg-Galc^twi Ptgdr^tm1Sna Allelic Composition: Galc^twi-4J/Galc^twi-4J Genetic Background: involves: C57BL/6J
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J Allelic Composition: Galc^twi-2J/Galc^twi-2J Genetic Background: B10.A-H2ⁱ⁵/(R5)SgSn
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0001524	impaired limb coordination	"reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Cd79b^tm3Mnz/Cd79b^tm3Mnz Genetic Background: involves: 129/Sv * C57BL/6
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh Genetic Background: B6.129-Gpx1^tm1Ysh
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh Genetic Background: B6.129-Gpx1^tm1Ysh Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi,Hpgds^tm1Urad/Hpgds^tm1Urad Genetic Background: B6.Cg-Hpgds^tm1Urad Galc^twi Allelic Composition: Galc^twi/Galc^twi,Ptgdr^tm1Sna/Ptgdr^tm1Sna Genetic Background: B6.Cg-Galc^twi Ptgdr^tm1Sna Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0002182	abnormal astrocyte morphology	"anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi,Hpgds^tm1Urad/Hpgds^tm1Urad Genetic Background: B6.Cg-Hpgds^tm1Urad Galc^twi Allelic Composition: Galc^twi/Galc^twi,Ptgdr^tm1Sna/Ptgdr^tm1Sna Genetic Background: B6.Cg-Galc^twi Ptgdr^tm1Sna Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0002183	gliosis	"increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J Allelic Composition: Galc^twi/Galc^twi,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0002446	abnormal macrophage morphology	"anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CE/J
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0002651	abnormal sciatic nerve	"malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0002828	abnormal glomerular capsule	"anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0002998	abnormal bone remodeling	"aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J
MP:0003799	impaired macrophage migration	"defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0003871	abnormal myelin sheath morphology	"malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CE/J
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0004967	abnormal kidney epithelium morphology	"any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: CE/J
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh Genetic Background: B6.129-Gpx1^tm1Ysh Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CE/J
MP:0005167	abnormal blood-brain barrier	"anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Galc^twi/Galc^twi,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J
MP:0005405	axon degeneration	"retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gpx1^tm1Ysh/Gpx1^tm1Ysh Genetic Background: B6.129-Gpx1^tm1Ysh Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0006043	decreased apoptosis	"less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Galc^twi/Galc^twi,Hpgds^tm1Urad/Hpgds^tm1Urad Genetic Background: B6.Cg-Hpgds^tm1Urad Galc^twi
MP:0006082	CNS inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J
MP:0008026	abnormal brain white matter morphology	"any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J
MP:0008027	abnormal spinal cord white matter morphology	"any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: CE/J
MP:0008246	abnormal leukocyte morphology	"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J
MP:0008469	abnormal protein level	"anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: CE/J
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: Galc^twi/Galc^twi,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J
MP:0008911	induced hyperactivity	"increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0008917	abnormal oligodendrocyte physiology	"any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0009046	muscle twitch	"minor, sometimes imperceptible, local muscle contractions or uncontrollable movement of a single muscle group served by a single motor nerve fiber or filament sometime, but not always, indicating a neurological disorder" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0009434	paraparesis	"a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0009640	abnormal renal tubule epithelium morphology	"any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi,Glb1^tm1Adz/Glb1^tm1Adz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J
MP:0009808	reduced oligodendrocyte number	"significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: CE/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0009823	abnormal sphingomyelin level	"deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0009978	abnormal cerebellum white matter morphology		Show Allelic Composition: Galc^twi/Galc^twi,Il6^tm1Kopf/Il6^tm1Kopf Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J Allelic Composition: Galc^twi/Galc^twi,Il6⁺/? Genetic Background: involves: 129S2/SvPas * C57BL/6J * CE/J
MP:0010047	axonal spheroids	"focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J
MP:0010170	abnormal glial cell apoptosis	"change in the timing or the number of glial cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: involves: CE/J
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0010892	increased oligodendrocyte progenitor number	"greater number of cells that differentiate into a type of glial cell in the central nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Galc^twi-5J/Galc^twi-5J Genetic Background: BXD32/TyJ-Galc^twi-5J/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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