ENSMUSG00000021040


Mus musculus

Features
Gene ID: ENSMUSG00000021040
  
Biological name :Slirp
  
Synonyms : Q9D8T7 / Slirp / SRA stem-loop interacting RNA binding protein
  
Possible biological names infered from orthology : Q9GZT3
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D2
Gene start: 87443896
Gene end: 87452206
  
Corresponding Affymetrix probe sets: 10397530 (MoGene1.0st)   1428554_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076673
Ensembl peptide - ENSMUSP00000124174
Ensembl peptide - ENSMUSP00000125341
Ensembl peptide - ENSMUSP00000125727
NCBI entrez gene - 380773     See in Manteia.
MGI - MGI:1916394
RefSeq - NM_026958
RefSeq Peptide - NP_081234
swissprot - Q9D8T7
swissprot - F7DE82
swissprot - F8WHU8
swissprot - Q14AR0
Ensembl - ENSMUSG00000021040
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slirpENSDARG00000097753Danio rerio
 SLIRPENSGALG00000031238Gallus gallus
 SLIRPENSG00000119705Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034152  SLIRP, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000961 negative regulation of mitochondrial RNA catabolic process IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0009834 abnormal sperm annulus morphology "any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]
Show

Allelic Composition: Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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