ENSMUSG00000021177


Mus musculus

Features
Gene ID: ENSMUSG00000021177
  
Biological name :Tdp1
  
Synonyms : Tdp1 / tyrosyl-DNA phosphodiesterase 1
  
Possible biological names infered from orthology : Q9NUW8
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 99884517
Gene end: 99955219
  
Corresponding Affymetrix probe sets: 10397717 (MoGene1.0st)   10397719 (MoGene1.0st)   1426492_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021594
Ensembl peptide - ENSMUSP00000123269
Ensembl peptide - ENSMUSP00000118656
NCBI entrez gene - 104884     See in Manteia.
MGI - MGI:1920036
RefSeq - NM_028354
RefSeq - XM_006515363
RefSeq - XM_006515364
RefSeq Peptide - NP_082630
swissprot - B8JJC1
swissprot - D3Z075
Ensembl - ENSMUSG00000021177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdp1ENSDARG00000073866Danio rerio
 TDP1ENSGALG00000010669Gallus gallus
 TDP1ENSG00000042088Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010347  Tyrosyl-DNA phosphodiesterase I
 IPR027415  Tyrosyl-DNA phosphodiesterase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0017005 3"-tyrosyl-DNA phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0010947 abnormal single-strand DNA break repair "anomaly in the process of repair of single strand breaks in DNA; repair of such breaks is mediated by the same enzyme systems as are used in base excision repair" [GO:0000012]
Show

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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