ENSMUSG00000021245


Mus musculus

Features
Gene ID: ENSMUSG00000021245
  
Biological name :Mlh3
  
Synonyms : Mlh3 / mutL homolog 3
  
Possible biological names infered from orthology : Q9UHC1
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D1
Gene start: 85234520
Gene end: 85270599
  
Corresponding Affymetrix probe sets: 10401616 (MoGene1.0st)   1426052_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152840
Ensembl peptide - ENSMUSP00000019378
Ensembl peptide - ENSMUSP00000129900
Ensembl peptide - ENSMUSP00000152686
NCBI entrez gene - 217716     See in Manteia.
MGI - MGI:1353455
RefSeq - XM_006515706
RefSeq - NM_001304475
RefSeq - NM_175337
RefSeq - XM_006515703
RefSeq - XM_006515704
RefSeq Peptide - NP_780546
RefSeq Peptide - NP_001291404
swissprot - A0A1Y7VMP7
swissprot - Q68FG1
swissprot - A0A1Y7VJX4
Ensembl - ENSMUSG00000021245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlh3ENSDARG00000056334Danio rerio
 MLH3ENSGALG00000010304Gallus gallus
 MLH3ENSG00000119684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR013507  DNA mismatch repair protein, S5 domain 2-like
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR014762  DNA mismatch repair, conserved site
 IPR014790  MutL, C-terminal, dimerisation
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR028830  DNA mismatch repair protein Mlh3
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily
 IPR037198  MutL, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006298 mismatch repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0007131 reciprocal meiotic recombination IEA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007144 female meiosis I IMP
 biological_processGO:0008104 protein localization IMP
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005712 chiasma IDA
 cellular_componentGO:0032300 mismatch repair complex IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0019237 centromeric DNA binding IDA
 molecular_functionGO:0030983 mismatched DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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