ENSMUSG00000021302


Mus musculus

Features
Gene ID: ENSMUSG00000021302
  
Biological name :Ggps1
  
Synonyms : Geranylgeranyl pyrophosphate synthase / Ggps1 / Q9WTN0
  
Possible biological names infered from orthology : geranylgeranyl diphosphate synthase 1 / O95749
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 14050659
Gene end: 14063488
  
Corresponding Affymetrix probe sets: 10407833 (MoGene1.0st)   1419505_a_at (Mouse Genome 430 2.0 Array)   1419506_at (Mouse Genome 430 2.0 Array)   1419805_s_at (Mouse Genome 430 2.0 Array)   1429356_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152355
Ensembl peptide - ENSMUSP00000152428
Ensembl peptide - ENSMUSP00000152789
Ensembl peptide - ENSMUSP00000152754
Ensembl peptide - ENSMUSP00000152753
Ensembl peptide - ENSMUSP00000152649
Ensembl peptide - ENSMUSP00000152645
Ensembl peptide - ENSMUSP00000152512
Ensembl peptide - ENSMUSP00000126603
Ensembl peptide - ENSMUSP00000152305
NCBI entrez gene - 14593     See in Manteia.
MGI - MGI:1341724
RefSeq - XM_017315386
RefSeq - XM_017315385
RefSeq - XM_011244280
RefSeq - XM_006516549
RefSeq - XM_006516548
RefSeq - XM_017315384
RefSeq - XM_011244281
RefSeq - NM_010282
RefSeq - XM_017315388
RefSeq - XM_017315387
RefSeq Peptide - NP_034412
RefSeq Peptide - NP_001318048
RefSeq Peptide - NP_001318105
RefSeq Peptide - NP_001318106
RefSeq Peptide - NP_001318107
swissprot - Q9WTN0
swissprot - Q9CZZ6
swissprot - Q3V0T8
swissprot - A0A1Y7VNV0
swissprot - A0A1Y7VJZ1
swissprot - A0A1Y7VLK7
swissprot - A0A1Y7VLQ5
swissprot - A0A1Y7VM16
swissprot - A0A1Y7VMJ4
swissprot - A0A1Y7VNC9
Ensembl - ENSMUSG00000021302
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ggps1ENSDARG00000023627Danio rerio
 GGPS1ENSGALG00000042853Gallus gallus
 GGPS1ENSG00000152904Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000092  Polyprenyl synthetase
 IPR008949  Isoprenoid synthase domain superfamily
 IPR033749  Polyprenyl synthetase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006720 isoprenoid metabolic process ISS
 biological_processGO:0008299 isoprenoid biosynthetic process IEA
 biological_processGO:0033384 geranyl diphosphate biosynthetic process IEA
 biological_processGO:0033386 geranylgeranyl diphosphate biosynthetic process IEA
 biological_processGO:0045337 farnesyl diphosphate biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004161 dimethylallyltranstransferase activity IEA
 molecular_functionGO:0004311 farnesyltranstransferase activity ISS
 molecular_functionGO:0004337 geranyltranstransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021302 Ggps1 / Q9WTN0 / Geranylgeranyl pyrophosphate synthase / O95749* / geranylgeranyl diphosphate synthase 1*  / complex






 

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contact: otassy@igbmc.fr