ENSMUSG00000021362


Mus musculus

Features
Gene ID: ENSMUSG00000021362
  
Biological name :Gcm2
  
Synonyms : Gcm2 / glial cells missing homolog 2
  
Possible biological names infered from orthology : O75603
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 41101427
Gene end: 41111035
  
Corresponding Affymetrix probe sets: 10408828 (MoGene1.0st)   1420455_at (Mouse Genome 430 2.0 Array)   1420456_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021791
Ensembl peptide - ENSMUSP00000153244
NCBI entrez gene - 107889     See in Manteia.
MGI - MGI:1861438
RefSeq - NM_008104
RefSeq - XM_017315354
RefSeq Peptide - NP_032130
swissprot - A0A286YD23
swissprot - A0A0R4J021
Ensembl - ENSMUSG00000021362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcm2ENSDARG00000045413Danio rerio
 GCM2ENSGALG00000012768Gallus gallus
 GCM2ENSG00000124827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gcm1 / P70348 / Chorion-specific transcription factor GCMa / Q9NP62* / glial cells missing homolog 1*ENSMUSG0000002333329


Protein motifs (from Interpro)
Interpro ID Name
 IPR003902  Transcription regulator GCM domain
 IPR036115  GCM domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030643 cellular phosphate ion homeostasis IEA
 biological_processGO:0060017 parathyroid gland development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

 MP:0000680 absent parathyroid glands "missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

Allelic Composition: Gcm2tm1Kry/Gcm2tm1Kry
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm1.1Dhy/Mecp2+
Genetic Background: C57BL/6N-Mecp2tm1.1Dhy

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0003433 decreased activity of parathyroid "reduced function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

 MP:0003494 parathyroid hypoplasia 
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

 MP:0006339 abnormal third branchial arch morphology "anomaly in the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcm2tm1Kry/Gcm2tm1Kry
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Gcm1tm1Hoso/Gcm1tm1Hoso,Gcm2tm1Hoso/Gcm2tm1Hoso
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Gcm1tm1Hoso/Gcm1tm1Hoso,Gcm2tm1Hoso/Gcm2tm1Hoso
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Hfe2tm1Arbr/Hfe2tm1Arbr
Genetic Background: involves: 129S4 * 129X1/SvJ

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Gcm1tm1Hoso/Gcm1tm1Hoso,Gcm2tm1Hoso/Gcm2tm1Hoso
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0013573 abnormal parathyroid gland development "aberrant formation or incomplete differentiation of either of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH), a hormone that regulates calcium and phosphorous metabolism; in mouse, the parathyroids develop with the thymus from two common parathyroid/thymus primordia originating from the third pharyngeal pouch endoderm; the third pharyngeal pouches are formed at E9.5-E10 and are patterned into dorsal/anterior parathyroid and ventral/posterior thymus domains; the third pouch endoderm proliferates to form bilateral parathyroid/thymus common primordia at E11-E11.5; each primordium separates into one parathyroid gland and one thymus lobe at E12.5-E13.5, which then migrate to their eventual adult locations by about E14.5; in the adult mouse, the parathyroids are located near or embedded within the thyroid gland, and the thymus is situated in the anterior chest cavity" [MGI:Anna, PMID:17382312]
Show

Allelic Composition: Gcm2tm1Kry/Gcm2tm1Kry
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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