Manteia - Molecule gene

ENSMUSG00000021569

Mus musculus

Features

Gene ID:	ENSMUSG00000021569

Biological name :	Trip13

Synonyms :	Q3UA06 / thyroid hormone receptor interactor 13 / Trip13

Possible biological names infered from orthology :	Q15645

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	C1
Gene start:	73911347
Gene end:	73937784

Corresponding Affymetrix probe sets:	10410560 (MoGene1.0st) 1429294_at (Mouse Genome 430 2.0 Array) 1429295_s_at (Mouse Genome 430 2.0 Array) 1446760_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000022053 Ensembl peptide - ENSMUSP00000152724 Ensembl peptide - ENSMUSP00000152604 NCBI entrez gene - 69716 See in Manteia. MGI - MGI:1916966 RefSeq - NM_027182 RefSeq Peptide - NP_081458 swissprot - A0A1Y7VLR4 swissprot - A0A1Y7VK03 swissprot - Q3UA06 Ensembl - ENSMUSG00000021569

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
trip13	ENSDARG00000025043	Danio rerio
E1C6Q1	ENSGALG00000033834	Gallus gallus
Q15645	ENSG00000071539	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001270	ClpA/B family
IPR003593	AAA+ ATPase domain
IPR003959	ATPase, AAA-type, core
IPR003960	ATPase, AAA-type, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001556	oocyte maturation	IMP
biological_process	GO:0006302	double-strand break repair	IMP
biological_process	GO:0007094	mitotic spindle assembly checkpoint	IEA
biological_process	GO:0007130	synaptonemal complex assembly	IMP
biological_process	GO:0007131	reciprocal meiotic recombination	IMP
biological_process	GO:0007141	male meiosis I	IMP
biological_process	GO:0007144	female meiosis I	IMP
biological_process	GO:0007283	spermatogenesis	IMP
biological_process	GO:0007286	spermatid development	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0048477	oogenesis	IMP
biological_process	GO:0051321	meiotic cell cycle	IEA
cellular_component	GO:0001673	male germ cell nucleus	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0000589	thin tail	"a tail with a smaller diameter than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0001116	small gonad	"reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0001129	impaired ovarian folliculogenesis	"a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0002777	absent ovarian follicles	"lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0003929	decreased heart rate variability	"reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005103	abnormal retinal pigmentation	"anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005168	abnormal female meiosis	"malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005385	cardiovascular system phenotype		Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005431	oocyte depletion	"reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008058	abnormal DNA repair	"any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0008261	arrest of male meiosis	"cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008966	abnormal chiasmata formation	"atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009451	abnormal chromosome pairing during meiosis	"an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009452	abnormal synaptonemal complex	"an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Trip13^{Gt(CH0621)Wtsi}/Trip13^{Gt(CH0621)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010507	shortened RR interval	"reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Trip13^{tm1.1(KOMP)Vlcg}/Trip13^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Trip13^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010571	shortened ST segment	"reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010948	abnormal double-strand DNA break repair	"any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pdyn^tm1Zim/Pdyn^tm1Zim Genetic Background: involves: 129/Sv * C57BL/6
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr