Manteia - Molecule gene

ENSMUSG00000021595

Mus musculus

Features

Gene ID:	ENSMUSG00000021595

Biological name :	Nsun2

Synonyms :	Nsun2 / Q1HFZ0 / tRNA (cytosine(34)-C(5))-methyltransferase

Possible biological names infered from orthology :	NOP2/Sun RNA methyltransferase family member 2 / Q08J23

Species:	Mus musculus

Chr. number:	13
Strand:	1
Band:	B3
Gene start:	69533746
Gene end:	69635780

Corresponding Affymetrix probe sets:	10405971 (MoGene1.0st) 1423850_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000022087 Ensembl peptide - ENSMUSP00000105321 Ensembl peptide - ENSMUSP00000134962 Ensembl peptide - ENSMUSP00000135455 NCBI entrez gene - 28114 See in Manteia. MGI - MGI:107252 RefSeq - NM_145354 RefSeq Peptide - NP_663329 swissprot - Q1HFZ0 swissprot - H3BJF3 swissprot - H3BKN0 Ensembl - ENSMUSG00000021595

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nsun2	ENSDARG00000056665	Danio rerio
NSUN2	ENSGALG00000013064	Gallus gallus
NSUN2	ENSG00000037474	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001678	SAM-dependent methyltransferase RsmB/NOP2-type
IPR023267	RNA (C5-cytosine) methyltransferase
IPR023270	tRNA (C5-cytosine) methyltransferase, NCL1
IPR029063	S-adenosyl-L-methionine-dependent methyltransferase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007286	spermatid development	IMP
biological_process	GO:0008033	tRNA processing	IEA
biological_process	GO:0030488	tRNA methylation	ISO
biological_process	GO:0032259	methylation	IEA
biological_process	GO:0033313	meiotic cell cycle checkpoint	IMP
biological_process	GO:0048820	hair follicle maturation	IMP
biological_process	GO:0051301	cell division	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005819	spindle	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0033391	chromatoid body	IDA
molecular_function	GO:0000049	tRNA binding	IBA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0008168	methyltransferase activity	IEA
molecular_function	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	ISO
molecular_function	GO:0016740	transferase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000162	lordosis	"anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1.1Hon,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Hes1^{tm1(cre/ERT2)Lcm}/Hes1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
MP:0000427	abnormal hair cycle	"aberrant growth or asynchronous timing of the hair growth " [J:65302]	Show Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1.1Hon,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Hes1^{tm1(cre/ERT2)Lcm}/Hes1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nsun2^{tm1a(EUCOMM)Wtsi}
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000443	abnormal snout morphology	"anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001015	small superior cervical ganglion	"reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001231	abnormal basal cell layer morphology	"structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Nsun2^{tm1a(EUCOMM)Wtsi}
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1.1Hon,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Hes1^{tm1(cre/ERT2)Lcm}/Hes1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001349	excessive tearing	"an unusually high amount of fluid secreted by the lacrimal glands, often resulting in overflow of fluid from the eye" [hdene:Howard Dene, Mouse Genome Informatics Curator, J:38104]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1.1Hon,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Hes1^{tm1(cre/ERT2)Lcm}/Hes1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002161	abnormal fertility/fecundity	"reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002368	abnormal thymus capsule morphology	"anomalous structure or development of the fibrous connective tissue surrounding the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002932	abnormal joint	"defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003442	decreased circulating glycerol level	"lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003686	abnormal eye muscle morphology	"malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004160	retroesophageal right subclavian artery	"the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004174	abnormal spine curvature	"deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004268	abnormal optic stalk morphology	"any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004353	abnormal deltoid tuberosity morphology	"any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004463	basisphenoid bone foramen	"the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004613	fusion of vertebral arches	"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004666	absent stapedial artery	"absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004890	decreased energy expenditure	"decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005296	abnormal humerus morphology	"malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0008805	decreased circulating amylase level	"reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myo5a^{tm1a(KOMP)Wtsi}/Myo5a^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Myo5a^{tm1a(KOMP)Wtsi}/Wtsi Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0008858	abnormal hair cycle anagen phase	"anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1.1Hon,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Hes1^{tm1(cre/ERT2)Lcm}/Hes1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ Allelic Composition: Nsun2^{tm1c(EUCOMM)Wtsi}/Nsun2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/? Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0008861	abnormal hair shedding	"anomaly in the hair cycle changes the timing of the hair loss that normally follows the anagen phase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0008923	thoracoschisis	"congenital fissure of the chest wall" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008963	increased carbon dioxide production	"increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0009770	abnormal optic chiasm morphology	"an anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0010831	partial lethality	"the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0011655	abnormal systemic artery morphology	"any structural anomaly of the arteries that carry oxygenated blood away from the heart to the body, as opposed to the pulmonary arteries, which carry deoxygenated blood to the lungs" [MGI:csmith]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013600	testis degeneration	"a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0013826	absent hypoglossal canal	"absence of the bony canal in the occipital bone through which the hypoglossal nerve emerges from the skull" [ISBN:0683400088]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013834	thin hypoglossal nerve	"slender appearance of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013835	absent hypoglossal nerve	"absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013836	abnormal hypoglossal nerve topology	"abnormal position of the hypoglossal nerve " [MGI:csmith]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013840	absent segment of posterior cerebral artery	"absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013842	ductus venosus stenosis	"narrowing of the lumen of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [MGI:csmith]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013848	subcutaneous edema	"accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013875	trigeminal neuroma		Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013876	absent ductus venosus valve	"absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013877	abnormal ductus venosus valve morphology	"any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013928	thin motoric part of trigeminal nerve		Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013948	intraembryonal intestine elongation		Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013967	abnormal infrahyoid muscle connection		Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013969	reduced sympathetic cervical ganglion size		Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013992	persistent dorsal ophthalmic artery		Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013995	abnormal external carotid artery origin		Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0014001	abnormal vertebral artery topology	"abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]	Show Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Nsun2^{tm1a(EUCOMM)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr