ENSMUSG00000021629


Mus musculus

Features
Gene ID: ENSMUSG00000021629
  
Biological name :Slc30a5
  
Synonyms : Q8R4H9 / Slc30a5 / Zinc transporter 5
  
Possible biological names infered from orthology : Q8TAD4 / solute carrier family 30 member 5
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 100802648
Gene end: 100833427
  
Corresponding Affymetrix probe sets: 10411751 (MoGene1.0st)   1422497_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065764
Ensembl peptide - ENSMUSP00000153587
Ensembl peptide - ENSMUSP00000153319
NCBI entrez gene - 69048     See in Manteia.
MGI - MGI:1916298
RefSeq - NM_022885
RefSeq - XM_011244695
RefSeq Peptide - NP_075023
swissprot - A0A286YDV6
swissprot - Q8R4H9
swissprot - A0A286YD86
Ensembl - ENSMUSG00000021629
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DG36ENSDARG00000051921Danio rerio
 Q5ZLF4ENSGALG00000014787Gallus gallus
 Q8TAD4ENSG00000145740Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JKN1 / Slc30a7 / Zinc transporter 7 / Q8NEW0* / solute carrier family 30 member 7*ENSMUSG0000005441419
Q8BJM5 / Slc30a6 / Zinc transporter 6 / Q6NXT4* / solute carrier family 30 member 6*ENSMUSG0000002406911


Protein motifs (from Interpro)
Interpro ID Name
 IPR002524  Cation efflux protein
 IPR027469  Cation efflux transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006824 cobalt ion transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0006882 cellular zinc ion homeostasis IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061088 regulation of sequestering of zinc ion IBA
 biological_processGO:0071577 zinc ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IEA
 molecular_functionGO:0008324 cation transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Insulin processing
Zinc efflux and compartmentalization by the SLC30 family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0009292 increased inguinal fat pad weight 
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0009298 increased mesenteric fat pad weight 
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0009304 increased retroperitoneal fat pad weight 
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

 MP:0010637 sinus bradycardia "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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