ENSMUSG00000021770


Mus musculus

Features
Gene ID: ENSMUSG00000021770
  
Biological name :Samd8
  
Synonyms : Q9DA37 / Samd8 / sterile alpha motif domain containing 8
  
Possible biological names infered from orthology : Q96LT4
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 21750531
Gene end: 21798726
  
Corresponding Affymetrix probe sets: 10413125 (MoGene1.0st)   1434402_at (Mouse Genome 430 2.0 Array)   1453730_at (Mouse Genome 430 2.0 Array)   1458408_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022292
Ensembl peptide - ENSMUSP00000112803
Ensembl peptide - ENSMUSP00000117603
NCBI entrez gene - 67630     See in Manteia.
MGI - MGI:1914880
RefSeq - XM_006519460
RefSeq - NM_026283
RefSeq - XM_006519459
RefSeq Peptide - NP_080559
swissprot - Q14AQ4
swissprot - Q3UH82
swissprot - Q9DA37
swissprot - D6REI9
Ensembl - ENSMUSG00000021770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SAMD8ENSDARG00000074663Danio rerio
 SAMD8ENSGALG00000005004Gallus gallus
 SAMD8ENSG00000156671Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgms1 / Q8VCQ6 / Phosphatidylcholine:ceramide cholinephosphotransferase 1 / sphingomyelin synthase 1*ENSMUSG0000004045130
Sgms2 / Q9D4B1 / Phosphatidylcholine:ceramide cholinephosphotransferase 2 / Q8NHU3* / sphingomyelin synthase 2*ENSMUSG0000005093128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR025749  Sphingomyelin synthase-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006686 sphingomyelin biosynthetic process NAS
 biological_processGO:0046513 ceramide biosynthetic process IEA
 biological_processGO:1905373 ceramide phosphoethanolamine biosynthetic process IMP
 biological_processGO:2000303 regulation of ceramide biosynthetic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IBA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 molecular_functionGO:0002950 ceramide phosphoethanolamine synthase activity IMP
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0033188 sphingomyelin synthase activity IBA
 molecular_functionGO:0047493 ceramide cholinephosphotransferase activity IBA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dusp5tm1.1Skey/Dusp5+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Samd8tm2.2Kwi/Samd8tm2.2Kwi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009823 abnormal sphingomyelin level "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Samd8tm1.1Kwi/Samd8tm1.1Kwi,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129P2/OlaHsd

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Samd8tm1.1Kwi/Samd8tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Samd8tm2.2Kwi/Samd8tm2.2Kwi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Samd8tm1.1Kwi/Samd8tm1.1Kwi,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Samd8tm2.2Kwi/Samd8tm2.2Kwi,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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