ENSMUSG00000022026


Mus musculus

Features
Gene ID: ENSMUSG00000022026
  
Biological name :Olfm4
  
Synonyms : Mus musculus olfactomedin 4 (Olfm4), mRNA. / Olfm4 / Q3UZZ4
  
Possible biological names infered from orthology : olfactomedin 4 / Q6UX06
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D3
Gene start: 79984081
Gene end: 80023139
  
Corresponding Affymetrix probe sets: 10416689 (MoGene1.0st)   1437060_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086112
Ensembl peptide - ENSMUSP00000154285
NCBI entrez gene - 380924     See in Manteia.
MGI - MGI:2685142
RefSeq - XM_006519174
RefSeq - NM_001030294
RefSeq - NM_001351947
RefSeq Peptide - NP_001025465
RefSeq Peptide - NP_001338876
swissprot - Q3UZZ4
swissprot - D3YYD0
Ensembl - ENSMUSG00000022026
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-173a9.6ENSDARG00000087625Danio rerio
 si:ch211-173a9.6ENSDARG00000041960Danio rerio
 OLFM4ENSGALG00000016943Gallus gallus
 OLFM4ENSG00000102837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Olfm5 / olfactomedin 5ENSMUSG0000004426537
Q3V1G4 / Olfml2b / Olfactomedin-like protein 2B / Q68BL8* / olfactomedin like 2B*ENSMUSG0000003846320
Olfm3 / P63056 / olfactomedin 3 / Q96PB7*ENSMUSG0000002796520
Olfm1 / O88998 / olfactomedin 1 / Q99784*ENSMUSG0000002683320
Q8BHP7 / Olfml2a / olfactomedin-like 2A / Q68BL7*ENSMUSG0000004661819
Olfm2 / Q8BM13 / olfactomedin 2 / O95897*ENSMUSG0000003217219
Myoc / O70624 / myocilin / Q99972*ENSMUSG0000002669719
Gldn / Q8BMF8 / Gliomedin Gliomedin shedded ectodomain / Q6ZMI3* / gliomedin*ENSMUSG0000004616718
Olfml3 / olfactomedin like 3 / Q9NRN5*ENSMUSG0000002784814
Olfml1 / olfactomedin-like 1 / Q6UWY5*ENSMUSG000000510416


Protein motifs (from Interpro)
Interpro ID Name
 IPR003112  Olfactomedin-like domain
 IPR031221  Olfactomedin-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0050777 negative regulation of immune response IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0042581 specific granule IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tc-2H/T+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tc-2H/T+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Tc-2H/T+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008623 increased circulating interleukin-3 level "increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Tc-2H/T+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc-2H/T+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc-2H/T+
Genetic Background: involves: 101/H * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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