ENSMUSG00000022129


Mus musculus

Features
Gene ID: ENSMUSG00000022129
  
Biological name :Dct
  
Synonyms : Dct / L-dopachrome tautomerase / P29812
  
Possible biological names infered from orthology : dopachrome tautomerase / P40126
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E4
Gene start: 118012790
Gene end: 118052244
  
Corresponding Affymetrix probe sets: 10422249 (MoGene1.0st)   1418028_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022725
NCBI entrez gene - 13190     See in Manteia.
MGI - MGI:102563
RefSeq - NM_010024
RefSeq - XM_006518510
RefSeq Peptide - NP_034154
swissprot - P29812
Ensembl - ENSMUSG00000022129
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dctENSDARG00000006008Danio rerio
 DCTENSGALG00000016899Gallus gallus
 DCTENSG00000080166Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tyrp1 / P07147 / tyrosinase-related protein 1 / P17643*ENSMUSG0000000599447
Tyr / P11344 / tyrosinase / P14679*ENSMUSG0000000465139


Protein motifs (from Interpro)
Interpro ID Name
 IPR002227  Tyrosinase copper-binding domain
 IPR008922  Uncharacterised domain, di-copper centre


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002052 positive regulation of neuroblast proliferation IMP
 biological_processGO:0006583 melanin biosynthetic process from tyrosine IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0021847 ventricular zone neuroblast division IMP
 biological_processGO:0042438 melanin biosynthetic process IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048468 cell development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033162 melanosome membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0004167 dopachrome isomerase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Melanin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Dctslt-2J/Dctslt-2J
Genetic Background: NXSMC/EiJ

Allelic Composition: A/?,DctSlt-lt/DctSlt-lt
Genetic Background: involves: C3H/HeJ

Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: A/?,DctSlt-lt/Dct+
Genetic Background: involves: C3H/HeJ

Allelic Composition: DctSlt-lt3J/DctSlt-lt3J
Genetic Background: B6(Cg)-DctSlt-lt3J/J

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

Allelic Composition: a/a,DctSlt-lt/DctSlt-lt
Genetic Background: involves: C3H/HeJ

Allelic Composition: a/a,DctSlt-lt/Dct+
Genetic Background: involves: C3H/HeJ

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Wtsi

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: DctSlt-lt3J/DctSlt-lt3J
Genetic Background: B6(Cg)-DctSlt-lt3J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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