ENSMUSG00000022186


Mus musculus

Features
Gene ID: ENSMUSG00000022186
  
Biological name :Oxct1
  
Synonyms : Oxct1 / Q9D0K2 / Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
  
Possible biological names infered from orthology : 3-oxoacid CoA-transferase 1 / P55809
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 4026383
Gene end: 4155344
  
Corresponding Affymetrix probe sets: 10422608 (MoGene1.0st)   1428140_at (Mouse Genome 430 2.0 Array)   1436750_a_at (Mouse Genome 430 2.0 Array)   1449059_a_at (Mouse Genome 430 2.0 Array)   1455804_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106318
Ensembl peptide - ENSMUSP00000116343
NCBI entrez gene - 67041     See in Manteia.
MGI - MGI:1914291
RefSeq - NM_024188
RefSeq Peptide - NP_077150
swissprot - Q3UJQ9
swissprot - Q9D0K2
Ensembl - ENSMUSG00000022186
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oxct1aENSDARG00000013063Danio rerio
 oxct1bENSDARG00000054319Danio rerio
 OXCT1ENSGALG00000014846Gallus gallus
 OXCT1ENSG00000083720Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oxct2a / Q9JJN4 / Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial / OXCT2* / Q9BYC2* / 3-oxoacid CoA-transferase 2*ENSMUSG0000007643668
Oxct2b / OXCT2* / Q9BYC2* / 3-oxoacid CoA-transferase 2*ENSMUSG0000007643868


Protein motifs (from Interpro)
Interpro ID Name
 IPR004163  Coenzyme A transferase binding site
 IPR004164  Coenzyme A transferase active site
 IPR004165  Coenzyme A transferase family I
 IPR012791  3-oxoacid CoA-transferase, subunit B
 IPR012792  3-oxoacid CoA-transferase, subunit A
 IPR014388  3-oxoacid CoA-transferase
 IPR037171  NagB/RpiA transferase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042182 ketone catabolic process IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046950 cellular ketone body metabolic process IEA
 biological_processGO:0046952 ketone body catabolic process IEA
 biological_processGO:0060612 adipose tissue development IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0008260 3-oxoacid CoA-transferase activity IEA
 molecular_functionGO:0008410 CoA-transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Utilization of Ketone Bodies


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022186 Oxct1 / Q9D0K2 / Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial / P55809* / 3-oxoacid CoA-transferase 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr