ENSMUSG00000022257


Mus musculus

Features
Gene ID: ENSMUSG00000022257
  
Biological name :Laptm4b
  
Synonyms : Laptm4b / Lysosomal-associated transmembrane protein 4B / Q91XQ6
  
Possible biological names infered from orthology : lysosomal protein transmembrane 4 beta / Q86VI4
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 34238028
Gene end: 34284302
  
Corresponding Affymetrix probe sets: 10423593 (MoGene1.0st)   1416148_at (Mouse Genome 430 2.0 Array)   1436915_x_at (Mouse Genome 430 2.0 Array)   1438365_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154118
Ensembl peptide - ENSMUSP00000154241
Ensembl peptide - ENSMUSP00000022867
Ensembl peptide - ENSMUSP00000153935
NCBI entrez gene - 114128     See in Manteia.
MGI - MGI:1890494
RefSeq - NM_033521
RefSeq Peptide - NP_277056
swissprot - B2CZK6
swissprot - Q91XQ6
Ensembl - ENSMUSG00000022257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 laptm4bENSDARG00000035870Danio rerio
 LAPTM4BENSGALG00000045196Gallus gallus
 Q86VI4ENSG00000104341Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Laptm4a / lysosomal-associated protein transmembrane 4A / Q15012* / lysosomal protein transmembrane 4 alpha*ENSMUSG0000002058544


Protein motifs (from Interpro)
Interpro ID Name
 IPR004687  Lysosomal-associated transmembrane protein 4/5
 IPR018401  Lysosomal-associated transmembrane protein 4B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0032509 endosome transport via multivesicular body sorting pathway ISS
 biological_processGO:0032911 negative regulation of transforming growth factor beta1 production ISS
 biological_processGO:0097213 regulation of lysosomal membrane permeability ISO
 biological_processGO:1905166 negative regulation of lysosomal protein catabolic process ISO
 biological_processGO:1905671 regulation of lysosome organization ISO
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane ISO
 cellular_componentGO:0032585 multivesicular body membrane ISO
 cellular_componentGO:0042995 cell projection ISO
 cellular_componentGO:0097487 multivesicular body, internal vesicle ISO
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0097001 ceramide binding ISS
 molecular_functionGO:1902936 phosphatidylinositol bisphosphate binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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