ENSMUSG00000022353


Mus musculus

Features
Gene ID: ENSMUSG00000022353
  
Biological name :Mtss1
  
Synonyms : metastasis suppressor 1 / Mtss1
  
Possible biological names infered from orthology : MTSS1, I-BAR domain containing / O43312
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 58941234
Gene end: 59082005
  
Corresponding Affymetrix probe sets: 10428857 (MoGene1.0st)   1424826_s_at (Mouse Genome 430 2.0 Array)   1434036_at (Mouse Genome 430 2.0 Array)   1440847_at (Mouse Genome 430 2.0 Array)   1443729_at (Mouse Genome 430 2.0 Array)   1446284_at (Mouse Genome 430 2.0 Array)   1451496_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079239
Ensembl peptide - ENSMUSP00000153850
Ensembl peptide - ENSMUSP00000154064
Ensembl peptide - ENSMUSP00000154093
NCBI entrez gene - 211401     See in Manteia.
MGI - MGI:2384818
RefSeq - XM_017316532
RefSeq - NM_001146180
RefSeq - NM_144800
RefSeq - XM_011245547
RefSeq - XM_011245548
RefSeq - XM_017316531
RefSeq - XM_006520707
RefSeq - XM_006520709
RefSeq - XM_006520711
RefSeq - XM_006520712
RefSeq - XM_006520714
RefSeq - XM_006520717
RefSeq - XM_011245540
RefSeq - XM_011245541
RefSeq - XM_011245542
RefSeq - XM_011245543
RefSeq - XM_011245544
RefSeq - XM_011245545
RefSeq - XM_011245546
RefSeq Peptide - NP_001139652
RefSeq Peptide - NP_659049
swissprot - G3X9H7
Ensembl - ENSMUSG00000022353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTSS1ENSGALG00000041969Gallus gallus
 MTSS1ENSG00000170873Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtss1l / Q6P9S0 / MTSS1-like protein / Q765P7* / MTSS1L, I-BAR domain containing*ENSMUSG0000003376354


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain
 IPR013606  IMD/I-BAR domain
 IPR027267  AH/BAR domain superfamily
 IPR027682  I-BAR domain containing protein MIM
 IPR030127  I-BAR domain containing protein MIM/ABBA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007009 plasma membrane organization IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

Allelic Composition: Mtss1Gt(CSC156)Byg/Mtss1+
Genetic Background: B6.129P2-Mtss1Gt(CSC156)Byg

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0011707 impaired fibroblast cell migration "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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