ENSMUSG00000022407


Mus musculus

Features
Gene ID: ENSMUSG00000022407
  
Biological name :Adsl
  
Synonyms : adenylosuccinate lyase / Adsl / P54822
  
Possible biological names infered from orthology : P30566
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 80948490
Gene end: 80970946
  
Corresponding Affymetrix probe sets: 10425461 (MoGene1.0st)   1418372_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127593
Ensembl peptide - ENSMUSP00000146546
Ensembl peptide - ENSMUSP00000143222
Ensembl peptide - ENSMUSP00000143188
Ensembl peptide - ENSMUSP00000132524
Ensembl peptide - ENSMUSP00000132423
Ensembl peptide - ENSMUSP00000131998
Ensembl peptide - ENSMUSP00000129601
Ensembl peptide - ENSMUSP00000023043
NCBI entrez gene - 11564     See in Manteia.
MGI - MGI:103202
RefSeq - NM_009634
RefSeq Peptide - NP_033764
swissprot - E9PZI0
swissprot - A0A140LHU1
swissprot - A0A0G2JFL8
swissprot - A0A0G2JFI8
swissprot - E9Q3T7
swissprot - P54822
swissprot - E9Q242
swissprot - E9Q0A0
Ensembl - ENSMUSG00000022407
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adslENSDARG00000017049Danio rerio
 ADSLENSGALG00000012034Gallus gallus
 ADSLENSG00000239900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000362  Fumarate lyase family
 IPR004769  Adenylosuccinate lyase
 IPR008948  L-Aspartase-like
 IPR019468  Adenylosuccinate lyase C-terminal
 IPR020557  Fumarate lyase, conserved site
 IPR022761  Fumarate lyase, N-terminal
 IPR024083  Fumarase/histidase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006163 purine nucleotide metabolic process IEA
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006167 AMP biosynthetic process IEA
 biological_processGO:0006189 "de novo" IMP biosynthetic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009060 aerobic respiration IEA
 biological_processGO:0009152 purine ribonucleotide biosynthetic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0044208 "de novo" AMP biosynthetic process IEA
 biological_processGO:0051262 protein tetramerization IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity IEA


Pathways (from Reactome)
Pathway description
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022407 Adsl / P54822 / adenylosuccinate lyase / P30566*  / complex






 

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