ENSMUSG00000022415


Mus musculus

Features
Gene ID: ENSMUSG00000022415
  
Biological name :Syngr1
  
Synonyms : O55100 / synaptogyrin 1 / Syngr1
  
Possible biological names infered from orthology : O43759
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 80091334
Gene end: 80119501
  
Corresponding Affymetrix probe sets: 10425335 (MoGene1.0st)   1419289_a_at (Mouse Genome 430 2.0 Array)   1434661_at (Mouse Genome 430 2.0 Array)   1453772_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121716
Ensembl peptide - ENSMUSP00000009727
Ensembl peptide - ENSMUSP00000009728
Ensembl peptide - ENSMUSP00000120696
NCBI entrez gene - 20972     See in Manteia.
MGI - MGI:1328323
RefSeq - NM_207708
RefSeq - XM_006520695
RefSeq - NM_009303
RefSeq Peptide - NP_033329
RefSeq Peptide - NP_997591
swissprot - D3YWY9
swissprot - O55100
swissprot - Q3U6D7
swissprot - F6PZA3
Ensembl - ENSMUSG00000022415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syngr1aENSDARG00000002564Danio rerio
 SYNGR1ENSGALG00000027665Gallus gallus
 O43759ENSG00000100321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R191 / Syngr3 / Synaptogyrin-3 / O43761*ENSMUSG0000000702150
O55101 / Syngr2 / Synaptogyrin-2 / O43760*ENSMUSG0000004827745
Syngr4 / synaptogyrin 4 / O95473*ENSMUSG0000004023132


Protein motifs (from Interpro)
Interpro ID Name
 IPR008253  Marvel domain
 IPR016579  Synaptogyrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting ISO
 biological_processGO:0045055 regulated exocytosis IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IMP
 biological_processGO:0048499 synaptic vesicle membrane organization IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031594 neuromuscular junction IBA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0045202 synapse IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Syngr1tm1Sud/Syngr1tm1Sud
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Syngr1tm1Sud/Syngr1tm1Sud
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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