ENSMUSG00000022451


Mus musculus

Features
Gene ID: ENSMUSG00000022451
  
Biological name :Twf1
  
Synonyms : Q91YR1 / Twf1 / twinfilin actin binding protein 1
  
Possible biological names infered from orthology : Q12792
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 94577951
Gene end: 94589889
  
Corresponding Affymetrix probe sets: 10431802 (MoGene1.0st)   10555892 (MoGene1.0st)   1420873_at (Mouse Genome 430 2.0 Array)   1420874_at (Mouse Genome 430 2.0 Array)   1420875_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119302
Ensembl peptide - ENSMUSP00000023087
NCBI entrez gene - 19230     See in Manteia.
MGI - MGI:1100520
RefSeq - NM_008971
RefSeq - XM_006520638
RefSeq Peptide - NP_032997
swissprot - D3Z2H0
swissprot - Q91YR1
Ensembl - ENSMUSG00000022451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TWF1 (1 of many)ENSDARG00000115712Danio rerio
 twf1bENSDARG00000011661Danio rerio
 TWF1ENSGALG00000009595Gallus gallus
 TWF1ENSG00000151239Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Twf2 / Q9Z0P5 / twinfilin actin binding protein 2 / Q6IBS0*ENSMUSG0000002327767


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR028458  Twinfilin
 IPR029006  ADF-H/Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0042989 sequestering of actin monomers IDA
 biological_processGO:0043538 regulation of actin phosphorylation IEA
 biological_processGO:0051016 barbed-end actin filament capping IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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