ENSMUSG00000023277


Mus musculus

Features
Gene ID: ENSMUSG00000023277
  
Biological name :Twf2
  
Synonyms : Q9Z0P5 / Twf2 / twinfilin actin binding protein 2
  
Possible biological names infered from orthology : Q6IBS0
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 106203108
Gene end: 106215389
  
Corresponding Affymetrix probe sets: 10588466 (MoGene1.0st)   1431292_a_at (Mouse Genome 430 2.0 Array)   1439440_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139905
Ensembl peptide - ENSMUSP00000150626
Ensembl peptide - ENSMUSP00000150259
Ensembl peptide - ENSMUSP00000140617
Ensembl peptide - ENSMUSP00000140339
Ensembl peptide - ENSMUSP00000024047
NCBI entrez gene - 23999     See in Manteia.
MGI - MGI:1346078
RefSeq - NM_011876
RefSeq Peptide - NP_036006
swissprot - A0A087WPT3
swissprot - A0A1L1SU53
swissprot - Q9Z0P5
swissprot - A0A1L1STC8
swissprot - A0A087WRG4
Ensembl - ENSMUSG00000023277
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 twf2aENSDARG00000094792Danio rerio
 twf2bENSDARG00000009727Danio rerio
 TWF2ENSGALG00000003977Gallus gallus
 TWF2ENSG00000247596Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Twf1 / Q91YR1 / twinfilin actin binding protein 1 / Q12792*ENSMUSG0000002245167


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR028458  Twinfilin
 IPR029006  ADF-H/Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly ISO
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0032532 regulation of microvillus length IC
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISO
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0045773 positive regulation of axon extension ISO
 biological_processGO:0071300 cellular response to retinoic acid ISO
 biological_processGO:0071363 cellular response to growth factor stimulus ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IDA
 molecular_functionGO:0005080 protein kinase C binding ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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