ENSG00000247596


Homo sapiens

Features
Gene ID: ENSG00000247596
  
Biological name :TWF2
  
Synonyms : Q6IBS0 / TWF2 / twinfilin actin binding protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.2
Gene start: 52228610
Gene end: 52239260
  
Corresponding Affymetrix probe sets: 202009_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303908
Ensembl peptide - ENSP00000426464
NCBI entrez gene - 11344     See in Manteia.
OMIM - 607433
RefSeq - NM_007284
RefSeq Peptide - NP_009215
swissprot - D6RG15
swissprot - Q6IBS0
Ensembl - ENSG00000247596
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 twf2aENSDARG00000094792Danio rerio
 twf2bENSDARG00000009727Danio rerio
 TWF2ENSGALG00000003977Gallus gallus
 Twf2ENSMUSG00000023277Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TWF1 / Q12792 / twinfilin actin binding protein 1ENSG0000015123964


Protein motifs (from Interpro)
Interpro ID Name
 IPR002108  Actin-depolymerising factor homology domain
 IPR028458  Twinfilin
 IPR029006  ADF-H/Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010592 positive regulation of lamellipodium assembly IMP
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0032532 regulation of microvillus length IC
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0042989 sequestering of actin monomers ISS
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0051016 barbed-end actin filament capping ISS
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030016 myofibril ISS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0032420 stereocilium ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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