ENSMUSG00000022500


Mus musculus

Features
Gene ID: ENSMUSG00000022500
  
Biological name :Litaf
  
Synonyms : Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog / Litaf / Q9JLJ0
  
Possible biological names infered from orthology : lipopolysaccharide induced TNF factor / Q99732
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 10959275
Gene end: 11066157
  
Corresponding Affymetrix probe sets: 10437687 (MoGene1.0st)   10437695 (MoGene1.0st)   1416303_at (Mouse Genome 430 2.0 Array)   1416304_at (Mouse Genome 430 2.0 Array)   1439916_at (Mouse Genome 430 2.0 Array)   1448294_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123948
Ensembl peptide - ENSMUSP00000023143
Ensembl peptide - ENSMUSP00000112667
NCBI entrez gene - 56722     See in Manteia.
MGI - MGI:1929512
RefSeq - NM_019980
RefSeq - XM_006522427
RefSeq Peptide - NP_064364
swissprot - E0CYR5
swissprot - Q9JLJ0
Ensembl - ENSMUSG00000022500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 litafENSDARG00000103483Danio rerio
 LITAFENSGALG00000003217Gallus gallus
 LITAFENSG00000189067Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdip1 / Q9DB75 / Mus musculus cell death inducing Trp53 target 1 (Cdip1), transcript variant 5, mRNA. / Q9H305* / cell death inducing p53 target 1*ENSMUSG0000000407134
Gm5767 / predicted 5767 / AC022167.5*ENSMUSG0000010725220


Protein motifs (from Interpro)
Interpro ID Name
 IPR006629  LPS-induced tumour necrosis factor alpha factor
 IPR037519  LITAF domain containing protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0098559 cytoplasmic side of early endosome membrane ISS
 cellular_componentGO:0098560 cytoplasmic side of late endosome membrane ISO
 cellular_componentGO:0098574 cytoplasmic side of lysosomal membrane ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050699 WW domain binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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