ENSMUSG00000022508


Mus musculus

Features
Gene ID: ENSMUSG00000022508
  
Biological name :Bcl6
  
Synonyms : B-cell lymphoma 6 protein homolog / Bcl6 / P41183
  
Possible biological names infered from orthology : B cell CLL/lymphoma 6 / P41182
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 23965052
Gene end: 23988852
  
Corresponding Affymetrix probe sets: 10438738 (MoGene1.0st)   1421818_at (Mouse Genome 430 2.0 Array)   1450381_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023151
NCBI entrez gene - 12053     See in Manteia.
MGI - MGI:107187
RefSeq - XM_017316855
RefSeq - NM_009744
RefSeq Peptide - NP_033874
RefSeq Peptide - NP_001334955
swissprot - P41183
swissprot - Q544F9
Ensembl - ENSMUSG00000022508
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl6aENSDARG00000070864Danio rerio
 bcl6abENSDARG00000069295Danio rerio
 BCL6ENSGALG00000007357Gallus gallus
 BCL6ENSG00000113916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl6b / O88282 / B-cell CLL/lymphoma 6 member B protein / Q8N143* / B cell CLL/lymphoma 6B*ENSMUSG0000000031735
Q8R0A2 / Zbtb44 / zinc finger and BTB domain containing 44 / Q8NCP5*ENSMUSG0000004741215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002467 germinal center formation IMP
 biological_processGO:0002829 negative regulation of type 2 immune response IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007266 Rho protein signal transduction IGI
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030183 B cell differentiation IGI
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0031065 positive regulation of histone deacetylation IGI
 biological_processGO:0032764 negative regulation of mast cell cytokine production IMP
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IMP
 biological_processGO:0042092 type 2 immune response IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0043380 regulation of memory T cell differentiation IMP
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IEA
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IGI
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048294 negative regulation of isotype switching to IgE isotypes IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0051272 positive regulation of cellular component movement IMP
 biological_processGO:2000773 negative regulation of cellular senescence IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001161 intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf,Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt,Bcl6btm2Dent/Bcl6btm2Dent
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt,Bcl6btm2Dent/Bcl6btm2Dent
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Bcl6tm1.1Dent/Bcl6tm1.1Dent,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1.1Fsl/Epas1+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf,Ighmtm1(Bcl6)Rdf/?
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm2Tng,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002440 abnormal memory B cell morphology/development "anomalous structure, differentiation, or number of cells of the B lymphocyte lineage that do not secrete antibody after an intitial contact with antigen, but can be rapidly activated after a second challenge with the same antigen" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm2Tng,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1.1Kasm/Il2tm1.1Kasm,Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Bcl6tm1.1Jwan/Bcl6tm1.1Jwan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

Allelic Composition: Bcl6tm1.1Dent/Bcl6tm1.1Dent,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

 MP:0008179 absent germinal center B cells "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008194 abnormal memory B cell physiology "abnormal function of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl6tm1Rdf/Bcl6tm1Rdf
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Bcl6tm1.1Dent/Bcl6tm1.1Dent,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Bcl6tm1.1Dent/Bcl6tm1.1Dent,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010187 decreased T follicular helper cell number "reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2

Allelic Composition: Bcl6tm1.1Meln/Bcl6tm1.1Meln
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Bcl6tm1.1Dent/Bcl6tm1.1Dent,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

 MP:0010188 abnormal T follicular helper cell differentiation "atypical production of or inability to produce the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Bcl6tm1.1Dent/Bcl6tm1.1Dent,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

 MP:0010674 increased activation-induced B cell apoptosis "increased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bcl6tm1Sdt/Bcl6tm1Sdt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bcl6tm2Rdf/Bcl6tm2Rdf
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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