ENSG00000113916


Homo sapiens

Features
Gene ID: ENSG00000113916
  
Biological name :BCL6
  
Synonyms : B cell CLL/lymphoma 6 / BCL6 / P41182
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q27.3
Gene start: 187721377
Gene end: 187745727
  
Corresponding Affymetrix probe sets: 203140_at (Human Genome U133 Plus 2.0 Array)   215990_s_at (Human Genome U133 Plus 2.0 Array)   228758_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398014
Ensembl peptide - ENSP00000413122
Ensembl peptide - ENSP00000479784
Ensembl peptide - ENSP00000415574
Ensembl peptide - ENSP00000414455
Ensembl peptide - ENSP00000232014
Ensembl peptide - ENSP00000384371
NCBI entrez gene - 604     See in Manteia.
OMIM - 109565
RefSeq - NM_001706
RefSeq - XM_011513062
RefSeq - XM_005247694
RefSeq - NM_001130845
RefSeq - NM_001134738
RefSeq Peptide - NP_001124317
RefSeq Peptide - NP_001128210
RefSeq Peptide - NP_001697
swissprot - C9JCS5
swissprot - P41182
swissprot - C9JL16
swissprot - A0A0C4DH53
Ensembl - ENSG00000113916
  
Related genetic diseases (OMIM): 109565 - Lymphoma, B-cell

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl6aENSDARG00000070864Danio rerio
 bcl6abENSDARG00000069295Danio rerio
 BCL6ENSGALG00000007357Gallus gallus
 Bcl6ENSMUSG00000022508Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL6B / Q8N143 / B cell CLL/lymphoma 6BENSG0000016194035
Q8NCP5 / ZBTB44 / zinc finger and BTB domain containing 44ENSG0000019632319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IGI
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002467 germinal center formation IEA
 biological_processGO:0002634 regulation of germinal center formation NAS
 biological_processGO:0002829 negative regulation of type 2 immune response IEA
 biological_processGO:0002903 negative regulation of B cell apoptotic process NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0032764 negative regulation of mast cell cytokine production IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0042092 type 2 immune response IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043380 regulation of memory T cell differentiation IEA
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated NAS
 biological_processGO:0048294 negative regulation of isotype switching to IgE isotypes IEA
 biological_processGO:0048821 erythrocyte development IEA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0050776 regulation of immune response NAS
 biological_processGO:0051272 positive regulation of cellular component movement IEA
 biological_processGO:1903464 negative regulation of mitotic cell cycle DNA replication NAS
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001161 intronic transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001004 Lymphedema 
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 HP:0001287 Meningitis 
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 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
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 HP:0001824 Weight loss 
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 HP:0001945 Fever 
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 HP:0002202 Pleural effusion "The presence of an excessive amount of fluid in the pleural cavity." [HPO:curators]
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 HP:0002585 Abnormality of the peritoneum 
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 HP:0002665 Lymphoma "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." [HPO:curators]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0030166 Night sweats "Occurence of excessive sweating during sleep." [HPO:probinson, pmid:23136329]
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 HP:0100721 Mediastinal lymphadenopathy 
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 HP:0200036 skin nodules "Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat." [HPO:SKOEHLER]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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