| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0000644 | dextrocardia | "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0000650 | mesocardia | "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0000747 | muscle weakness | "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
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| MP:0001274 | curly vibrissae | "whiskers twisted into coils or spirals" [J:47620] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
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| MP:0001706 | abnormal left-right axis patterning | "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
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| MP:0002075 | abnormal coat color | "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1.1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: C3H/HeJ-Mgrn1md-2J
Allelic Composition: Mgrn1md-4J/Mgrn1md-4J
Genetic Background: C3H/HeJ-Mgrn1md-4J
Allelic Composition: Mgrn1md-5J/Mgrn1md-5J
Genetic Background: C3H/HeJ
Allelic Composition: Mgrn1md-6J/Mgrn1md-6J
Genetic Background: C3H/HeJ-Mgrn1md-6J
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| MP:0002080 | prenatal lethality | "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
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| MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0002654 | spongiform encephalopathy | "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
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| MP:0002766 | situs inversus | "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0003178 | left pulmonary isomerism | "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
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| MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0005409 | darkened coat color | "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md/Mgrn1md
Genetic Background: C3H/HeJ-Mgrn1md/J
Allelic Composition: Mgrn1md-4J/Mgrn1md-4J
Genetic Background: C3H/HeJ-Mgrn1md-4J
Allelic Composition: Mgrn1md-5J/Mgrn1md-5J
Genetic Background: C3H/HeJ
Allelic Composition: Mgrn1md-6J/Mgrn1md-6J
Genetic Background: C3H/HeJ-Mgrn1md-6J
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0008025 | brain vacuoles | "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
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| MP:0010334 | pleural effusion | "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0010426 | abnormal heart and great artery attachment | "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0010436 | abnormal coronary sinus morphology | "any structural anomaly of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occuring between the inferior vena cava and the atrioventricular orifice" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0010488 | abnormal left subclavian artery morphology | "any structural anomaly of the artery that extends from the aortic arch to the left side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0010854 | lung situs inversus | "anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Mgrn1md-2J/Mgrn1md-2J
Genetic Background: involves: 129S1/SvImJ * C3H/HeJ
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