ENSMUSG00000022589


Mus musculus

Features
Gene ID: ENSMUSG00000022589
  
Biological name :Cyp11b2
  
Synonyms : Cyp11b2 / cytochrome P450, family 11, subfamily b, polypeptide 2
  
Possible biological names infered from orthology : CYP11B1 / cytochrome P450 family 11 subfamily B member 1 / cytochrome P450 family 11 subfamily B member 2 / P15538 / P19099
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 74851010
Gene end: 74856318
  
Corresponding Affymetrix probe sets: 10429547 (MoGene1.0st)   1450574_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131503
NCBI entrez gene - 13072     See in Manteia.
MGI - MGI:88584
RefSeq - NM_009991
RefSeq Peptide - NP_034121
swissprot - G3UWE4
Ensembl - ENSMUSG00000022589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp11c1ENSDARG00000042014Danio rerio
 P15538ENSG00000160882Homo sapiens
 P19099ENSG00000179142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp11b1 / cytochrome P450, family 11, subfamily b, polypeptide 1 / P15538* / P19099* / CYP11B2* / cytochrome P450 family 11 subfamily B member 2* / cytochrome P450 family 11 subfamily B member 1*ENSMUSG0000007560480
Q9QZ82 / Cyp11a1 / Cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / cytochrome P450 family 11 subfamily A member 1*ENSMUSG0000003232336
O35084 / Cyp27b1 / 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial / O15528* / cytochrome P450 family 27 subfamily B member 1*ENSMUSG0000000672428
Q64441 / Cyp24a1 / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / Q07973* / cytochrome P450 family 24 subfamily A member 1*ENSMUSG0000003856725
Q9DBG1 / Cyp27a1 / Sterol 26-hydroxylase, mitochondrial / Q02318* / cytochrome P450 family 27 subfamily A member 1*ENSMUSG0000002617025
Q64459 / Cyp3a11 / Cytochrome P450 3A11 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000005603521
P36423 / Tbxas1 / thromboxane A synthase 1, platelet / P24557* / thromboxane A synthase 1*ENSMUSG0000002992521
Q64464 / Cyp3a13 / Cytochrome P450 3A13 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002972720
Q64481 / Cyp3a16 / Cytochrome P450 3A16 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000003865620
Q9JMA7 / Cyp3a41b / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555220
Cyp3a44 / cytochrome P450, family 3, subfamily a, polypeptide 44 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000005441720
Q9JMA7 / Cyp3a41a / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555120
O09158 / Cyp3a25 / Cytochrome P450 3A25 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002963019
Cyp3a57 / cytochrome P450, family 3, subfamily a, polypeptide 57 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000007041919
Cyp3a59 / cytochrome P450, family 3, subfamily a, polypeptide 59 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000006129219
Q9WVK8 / Cyp46a1 / Cholesterol 24-hydroxylase / Q9Y6A2* / cytochrome P450 family 46 subfamily A member 1*ENSMUSG0000002125919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002399  Cytochrome P450, mitochondrial
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Mineralocorticoid biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008291 abnormal adrenocortical cell morphology "any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008293 abnormal zona glomerulosa morphology "any structural anomaly of the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced" [MESH:A06.407.071.140.960, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Cyp11b2tm1.1(cre)Brlt/Cyp11b2+,Nr5a1tm2Klp/Nr5a1tm2Klp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: B6.Cg-Ptpn22tm2Achn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr