ENSMUSG00000026170


Mus musculus

Features
Gene ID: ENSMUSG00000026170
  
Biological name :Cyp27a1
  
Synonyms : Cyp27a1 / Q9DBG1 / Sterol 26-hydroxylase, mitochondrial
  
Possible biological names infered from orthology : cytochrome P450 family 27 subfamily A member 1 / Q02318
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 74713574
Gene end: 74737892
  
Corresponding Affymetrix probe sets: 10347481 (MoGene1.0st)   1417590_at (Mouse Genome 430 2.0 Array)   1457665_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027356
NCBI entrez gene - 104086     See in Manteia.
MGI - MGI:88594
RefSeq - NM_024264
RefSeq - XM_006495607
RefSeq Peptide - NP_077226
swissprot - Q9DBG1
Ensembl - ENSMUSG00000026170
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp27a1.2ENSDARG00000069186Danio rerio
 cyp27a1.4ENSDARG00000055159Danio rerio
 cyp27a7ENSDARG00000033802Danio rerio
 zgc:136333ENSDARG00000088013Danio rerio
 CYP27A1ENSGALG00000002470Gallus gallus
 Q02318ENSG00000135929Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35084 / Cyp27b1 / 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial / O15528* / cytochrome P450 family 27 subfamily B member 1*ENSMUSG0000000672438
Q64441 / Cyp24a1 / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / Q07973* / cytochrome P450 family 24 subfamily A member 1*ENSMUSG0000003856729
Q9QZ82 / Cyp11a1 / Cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / cytochrome P450 family 11 subfamily A member 1*ENSMUSG0000003232324
Cyp11b2 / cytochrome P450, family 11, subfamily b, polypeptide 2 / P19099* / P15538* / CYP11B1* / cytochrome P450 family 11 subfamily B member 1* / cytochrome P450 family 11 subfamily B member 2*ENSMUSG0000002258923
Cyp11b1 / cytochrome P450, family 11, subfamily b, polypeptide 1 / P15538* / P19099* / CYP11B2* / cytochrome P450 family 11 subfamily B member 2* / cytochrome P450 family 11 subfamily B member 1*ENSMUSG0000007560423
Q64459 / Cyp3a11 / Cytochrome P450 3A11 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000005603522
Q9JMA7 / Cyp3a41b / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555222
Q64481 / Cyp3a16 / Cytochrome P450 3A16 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000003865622
Q9JMA7 / Cyp3a41a / Cytochrome P450 3A41 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P45...ENSMUSG0000007555122
Cyp3a44 / cytochrome P450, family 3, subfamily a, polypeptide 44 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000005441722
Q64464 / Cyp3a13 / Cytochrome P450 3A13 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002972721
Cyp3a57 / cytochrome P450, family 3, subfamily a, polypeptide 57 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000007041920
Cyp3a59 / cytochrome P450, family 3, subfamily a, polypeptide 59 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSMUSG0000006129220
Q9WVK8 / Cyp46a1 / Cholesterol 24-hydroxylase / Q9Y6A2* / cytochrome P450 family 46 subfamily A member 1*ENSMUSG0000002125920
P36423 / Tbxas1 / thromboxane A synthase 1, platelet / P24557* / thromboxane A synthase 1*ENSMUSG0000002992519
O09158 / Cyp3a25 / Cytochrome P450 3A25 / Q9HB55* / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readthrough* / cytochrome P450...ENSMUSG0000002963019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt
Genetic Background: B6.129-Cyp27a1tm1Elt/J

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt,Cyp2r1tm1(KOMP)Vlcg/Cyp2r1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/6NTac

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt
Genetic Background: B6.129-Cyp27a1tm1Elt/J

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt,Cyp2r1tm1(KOMP)Vlcg/Cyp2r1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/6NTac

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0000646 enlarged adrenocortical cells "larger size of cells of the adrenal gland " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0010393 shortened QRS complex duration "decrease in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt
Genetic Background: B6.129-Cyp27a1tm1Elt/J

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt,Cyp2r1tm1(KOMP)Vlcg/Cyp2r1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/6NTac

 MP:0012226 increased sterol level "greater level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [MGI:csmith]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0012338 decreased bile salt level "reduced level of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

 MP:0013307 increased adrenal gland weight "greater average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla " [MGI:Anna]
Show

Allelic Composition: Emdtm1Ykh/Y
Genetic Background: B6.129X1-Emdtm1Ykh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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