ENSMUSG00000022615


Mus musculus

Features
Gene ID: ENSMUSG00000022615
  
Biological name :Tymp
  
Synonyms : Q99N42 / thymidine phosphorylase / Tymp
  
Possible biological names infered from orthology : P19971
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 89371931
Gene end: 89377039
  
Corresponding Affymetrix probe sets: 10431546 (MoGene1.0st)   1432181_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023285
NCBI entrez gene - 72962     See in Manteia.
MGI - MGI:1920212
RefSeq - NM_138302
RefSeq Peptide - NP_612175
swissprot - Q99N42
Ensembl - ENSMUSG00000022615
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FQ377934.1ENSDARG00000099821Danio rerio
 TYMPENSG00000025708Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000053  Thymidine/pyrimidine-nucleoside phosphorylase
 IPR000312  Glycosyl transferase, family 3
 IPR013102  Pyrimidine nucleoside phosphorylase, C-terminal
 IPR017459  Glycosyl transferase family 3, N-terminal domain
 IPR018090  Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic
 IPR035902  Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
 IPR036320  Glycosyl transferase family 3, N-terminal domain superfamily
 IPR036566  Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance IEA
 biological_processGO:0006206 pyrimidine nucleobase metabolic process IEA
 biological_processGO:0006213 pyrimidine nucleoside metabolic process ISO
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0051969 regulation of transmission of nerve impulse IEA
 biological_processGO:1905333 regulation of gastric motility IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0004645 phosphorylase activity TAS
 molecular_functionGO:0009032 thymidine phosphorylase activity ISO
 molecular_functionGO:0016154 pyrimidine-nucleoside phosphorylase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0016763 transferase activity, transferring pentosyl groups ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Pyrimidine salvage
Pyrimidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi
Genetic Background: B6.129X1-Tymptm1Mihi

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: Not Specified

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sulf2Gt(XST155)Byg/Sulf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tymptm1Akiy/Tymptm1Akiy,Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi
Genetic Background: B6.129X1-Tymptm1Mihi

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tymptm1Akiy/Tymptm1Akiy,Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: involves: 129X1/SvJ

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sulf2Gt(XST155)Byg/Sulf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tymptm1Akiy/Tymptm1Akiy,Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: involves: 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi
Genetic Background: B6.129X1-Tymptm1Mihi

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0009980 abnormal cerebellum dentate nucleus morphology "any structural anomaly of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022615 Tymp / Q99N42 / thymidine phosphorylase / P19971*  / complex






 

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