ENSMUSG00000022678


Mus musculus

Features
Gene ID: ENSMUSG00000022678
  
Biological name :Nde1
  
Synonyms : Nde1 / Nuclear distribution 1 / Q9CZA6
  
Possible biological names infered from orthology : nudE neurodevelopment protein 1 / Q9NXR1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 14163275
Gene end: 14192928
  
Corresponding Affymetrix probe sets: 10433721 (MoGene1.0st)   1435737_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111461
Ensembl peptide - ENSMUSP00000118005
Ensembl peptide - ENSMUSP00000119355
Ensembl peptide - ENSMUSP00000023359
Ensembl peptide - ENSMUSP00000112817
NCBI entrez gene - 67203     See in Manteia.
MGI - MGI:1914453
RefSeq - XM_011246000
RefSeq - NM_001114085
RefSeq - NM_001285503
RefSeq - NM_001285504
RefSeq - NM_023317
RefSeq Peptide - NP_001272433
RefSeq Peptide - NP_075806
RefSeq Peptide - NP_001272432
RefSeq Peptide - NP_001107557
swissprot - F6Q325
swissprot - D6RJ36
swissprot - Q9CZA6
Ensembl - ENSMUSG00000022678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nde1ENSDARG00000103902Danio rerio
 NDE1ENSGALG00000032590Gallus gallus
 NDE1ENSG00000072864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndel1 / Q9ERR1 / Nuclear distribution protein nudE-like 1 / Q9GZM8* / nudE neurodevelopment protein 1 like 1*ENSMUSG0000001873655


Protein motifs (from Interpro)
Interpro ID Name
 IPR006964  NUDE domain
 IPR033494  NUDE family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IBA
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007020 microtubule nucleation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IBA
 biological_processGO:0007100 mitotic centrosome separation IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0021987 cerebral cortex development ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031023 microtubule organizing center organization IMP
 biological_processGO:0047496 vesicle transport along microtubule IGI
 biological_processGO:0051298 centrosome duplication IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051303 establishment of chromosome localization IBA
 biological_processGO:0051642 centrosome localization IBA
 biological_processGO:2000574 regulation of microtubule motor activity IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IBA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0031616 spindle pole centrosome IDA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IMP
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0000821 choroid plexus hyperplasia "increased cell number in the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0000923 abnormal roof plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the dorsal midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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