ENSMUSG00000018736


Mus musculus

Features
Gene ID: ENSMUSG00000018736
  
Biological name :Ndel1
  
Synonyms : Ndel1 / Nuclear distribution protein nudE-like 1 / Q9ERR1
  
Possible biological names infered from orthology : nudE neurodevelopment protein 1 like 1 / Q9GZM8
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 68821434
Gene end: 68871858
  
Corresponding Affymetrix probe sets: 10387180 (MoGene1.0st)   1422568_at (Mouse Genome 430 2.0 Array)   1424893_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018880
Ensembl peptide - ENSMUSP00000098579
Ensembl peptide - ENSMUSP00000104312
NCBI entrez gene - 83431     See in Manteia.
MGI - MGI:1932915
RefSeq - NM_023668
RefSeq - XM_006534540
RefSeq Peptide - NP_076157
swissprot - Q9ERR1
Ensembl - ENSMUSG00000018736
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndel1aENSDARG00000010953Danio rerio
 ndel1bENSDARG00000104225Danio rerio
 NDEL1ENSGALG00000001163Gallus gallus
 NDEL1ENSG00000166579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nde1 / Q9CZA6 / Nuclear distribution 1 / Q9NXR1* / nudE neurodevelopment protein 1*ENSMUSG0000002267855


Protein motifs (from Interpro)
Interpro ID Name
 IPR006964  NUDE domain
 IPR033493  Nuclear distribution protein nudE-like 1
 IPR033494  NUDE family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IBA
 biological_processGO:0000226 microtubule cytoskeleton organization IGI
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007020 microtubule nucleation IBA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0007100 mitotic centrosome separation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008090 retrograde axonal transport IDA
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0010975 regulation of neuron projection development IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032418 lysosome localization IMP
 biological_processGO:0033157 regulation of intracellular protein transport ISO
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0047496 vesicle transport along microtubule IGI
 biological_processGO:0048680 positive regulation of axon regeneration IEA
 biological_processGO:0051081 nuclear envelope disassembly ISS
 biological_processGO:0051303 establishment of chromosome localization IBA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0060052 neurofilament cytoskeleton organization IMP
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:1900029 positive regulation of ruffle assembly IMP
 biological_processGO:1990138 neuron projection extension IGI
 biological_processGO:2000574 regulation of microtubule motor activity IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IBA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IGI
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IDA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0043203 axon hillock IDA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0060053 neurofilament cytoskeleton IDA
 cellular_componentGO:0090724 central region of growth cone IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043014 alpha-tubulin binding IDA
 molecular_functionGO:0048487 beta-tubulin binding IDA
 molecular_functionGO:0070012 oligopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Gpx1tm1Mgr/Gpx1tm1Mgr
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Pafah1b1tm2.2Awb/Pafah1b1+,Ndel1tm1.1Shr/Ndel1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ndel1tm1.1Shr/Ndel1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ndel1tm1.1Shr/Ndel1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Gpx1tm1Mgr/Gpx1tm1Mgr
Genetic Background: involves: 129 * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ndel1tm1.1Shr/Ndel1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ndel1tm1.1Shr/Ndel1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpx1tm1Mgr/Gpx1tm1Mgr
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Pafah1b1tm2.2Awb/Pafah1b1+,Ndel1tm1.1Shr/Ndel1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gpx1tm1Mgr/Gpx1tm1Mgr
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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