ENSMUSG00000022721


Mus musculus

Features
Gene ID: ENSMUSG00000022721
  
Biological name :Trmt2a
  
Synonyms : Q8BNV1 / TRM2 tRNA methyltransferase 2A / Trmt2a
  
Possible biological names infered from orthology : Q8IZ69 / tRNA methyltransferase 2 homolog A
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 18248679
Gene end: 18254772
  
Corresponding Affymetrix probe sets: 10434148 (MoGene1.0st)   1434244_x_at (Mouse Genome 430 2.0 Array)   1441920_x_at (Mouse Genome 430 2.0 Array)   1448114_a_at (Mouse Genome 430 2.0 Array)   1448115_at (Mouse Genome 430 2.0 Array)   1453995_a_at (Mouse Genome 430 2.0 Array)   1457620_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111304
Ensembl peptide - ENSMUSP00000121216
Ensembl peptide - ENSMUSP00000133226
Ensembl peptide - ENSMUSP00000111303
Ensembl peptide - ENSMUSP00000117026
NCBI entrez gene - 15547     See in Manteia.
MGI - MGI:96270
RefSeq - XM_017316881
RefSeq - NM_001080999
RefSeq - NM_001081000
RefSeq - NM_001195205
RefSeq - XM_006521805
RefSeq Peptide - NP_001074469
RefSeq Peptide - NP_001182134
RefSeq Peptide - NP_001074468
swissprot - Q3UYU2
swissprot - E9PUQ7
swissprot - Q8BNV1
swissprot - F6ZHN3
swissprot - F6SY41
Ensembl - ENSMUSG00000022721
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trmt2aENSDARG00000002830Danio rerio
 TRMT2AENSGALG00000002094Gallus gallus
 Q8IZ69ENSG00000099899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BQJ6 / Trmt2b / TRM2 tRNA methyltransferase 2B / Q96GJ1* / tRNA methyltransferase 2 homolog B*ENSMUSG0000006736929


Protein motifs (from Interpro)
Interpro ID Name
 IPR010280  (Uracil-5)-methyltransferase family
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR034262  TRMT2A, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001510 RNA methylation IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0032259 methylation IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008173 RNA methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0013155 decreased KLRG1+ CD8 alpha beta T cell number "decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [MGI:csmith]
Show

Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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