ENSMUSG00000022724


Mus musculus

Features
Gene ID: ENSMUSG00000022724
  
Biological name :Riox2
  
Synonyms : Q8CD15 / ribosomal oxygenase 2 / Riox2
  
Possible biological names infered from orthology : Q8IUF8
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C1.3
Gene start: 59471775
Gene end: 59492461
  
Corresponding Affymetrix probe sets: 10436428 (MoGene1.0st)   1423595_at (Mouse Genome 430 2.0 Array)   1431939_a_at (Mouse Genome 430 2.0 Array)   1451042_a_at (Mouse Genome 430 2.0 Array)   1454066_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112950
Ensembl peptide - ENSMUSP00000125297
Ensembl peptide - ENSMUSP00000121743
Ensembl peptide - ENSMUSP00000023407
Ensembl peptide - ENSMUSP00000112899
NCBI entrez gene - 67014     See in Manteia.
MGI - MGI:1914264
RefSeq - XM_006522479
RefSeq - XM_006522480
RefSeq - NM_025910
RefSeq Peptide - NP_080186
swissprot - Q8CCK9
swissprot - Q8CD15
swissprot - D3Z287
swissprot - D3YTU3
Ensembl - ENSMUSG00000022724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 riox2ENSDARG00000036359Danio rerio
 MINAENSGALG00000039302Gallus gallus
 RIOX2ENSG00000170854Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Riox1 / Q9JJF3 / Ribosomal oxygenase 1 / Q9H6W3*ENSMUSG0000004679131


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006338 chromatin remodeling IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030961 peptidyl-arginine hydroxylation IBA
 biological_processGO:0034720 histone H3-K4 demethylation IEA
 biological_processGO:0042127 regulation of cell proliferation ISO
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IGI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032453 histone demethylase activity (H3-K4 specific) IBA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IBA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0008551 abnormal circulating interferon-gamma level "anomaly in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0008601 abnormal circulating interleukin-4 level "anomaly in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr