ENSMUSG00000046791


Mus musculus

Features
Gene ID: ENSMUSG00000046791
  
Biological name :Riox1
  
Synonyms : Q9JJF3 / Ribosomal oxygenase 1 / Riox1
  
Possible biological names infered from orthology : Q9H6W3
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D1
Gene start: 83950608
Gene end: 83952951
  
Corresponding Affymetrix probe sets: 10397143 (MoGene1.0st)   1448413_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057984
NCBI entrez gene - 71952     See in Manteia.
MGI - MGI:1919202
RefSeq - NM_023633
RefSeq Peptide - NP_076122
swissprot - Q9JJF3
Ensembl - ENSMUSG00000046791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 riox1ENSDARG00000067838Danio rerio
 C5H14ORF169ENSGALG00000020454Gallus gallus
 RIOX1ENSG00000170468Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Riox2 / Q8CD15 / ribosomal oxygenase 2 / Q8IUF8*ENSMUSG0000002272424


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain
 IPR013109  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030961 peptidyl-arginine hydroxylation IBA
 biological_processGO:0034720 histone H3-K4 demethylation IDA
 biological_processGO:0042254 ribosome biogenesis TAS
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0005506 iron ion binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IMP
 molecular_functionGO:0032453 histone demethylase activity (H3-K4 specific) IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009673 increased birth weight "increase in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011710 increased osteoblast differentiation 
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0030278 thick neurocranium "increased thickness of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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