ENSMUSG00000022821


Mus musculus

Features
Gene ID: ENSMUSG00000022821
  
Biological name :Hgd
  
Synonyms : Hgd / Homogentisate 1,2-dioxygenase / O09173
  
Possible biological names infered from orthology : Q93099
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 37580153
Gene end: 37632020
  
Corresponding Affymetrix probe sets: 10435626 (MoGene1.0st)   1452986_at (Mouse Genome 430 2.0 Array)   1458049_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125492
NCBI entrez gene - 15233     See in Manteia.
MGI - MGI:96078
RefSeq - NM_013547
RefSeq Peptide - NP_038575
swissprot - O09173
Ensembl - ENSMUSG00000022821
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hgdENSDARG00000058005Danio rerio
 HGDENSGALG00000014966Gallus gallus
 HGDENSG00000113924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005708  Homogentisate 1,2-dioxygenase
 IPR011051  RmlC-like cupin domain superfamily
 IPR014710  RmlC-like jelly roll fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process IMP
 biological_processGO:0006559 L-phenylalanine catabolic process IEA
 biological_processGO:0006570 tyrosine metabolic process IEA
 biological_processGO:0006572 tyrosine catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004411 homogentisate 1,2-dioxygenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Phenylalanine and tyrosine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003619 abnormal urine color "any alteration from the usual straw-coloration of the urine" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0013723 increased circulating tyrosine level "the amount of the amino acid histidine in the blood is more than expected" [MGI:csmith]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022821 Hgd / O09173 / Homogentisate 1,2-dioxygenase / Q93099*  / complex






 

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