ENSMUSG00000022853


Mus musculus

Features
Gene ID: ENSMUSG00000022853
  
Biological name :Ehhadh
  
Synonyms : Ehhadh / Peroxisomal bifunctional enzyme Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase 3-hydroxyacyl-CoA dehydrogenase / Q9DBM2
  
Possible biological names infered from orthology : enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase / Q08426
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 21761287
Gene end: 21787844
  
Corresponding Affymetrix probe sets: 10438575 (MoGene1.0st)   1448382_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023559
NCBI entrez gene - 74147     See in Manteia.
MGI - MGI:1277964
RefSeq - NM_023737
RefSeq - XM_006522658
RefSeq Peptide - NP_076226
swissprot - Q9DBM2
Ensembl - ENSMUSG00000022853
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ehhadhENSDARG00000070029Danio rerio
 EHHADHENSGALG00000006680Gallus gallus
 EHHADHENSG00000113790Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hadha / Q8BMS1 / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit / P40939* / hydroxyacyl-CoA dehydrogen...ENSMUSG0000002574529
Hadh / Q61425 / Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial / Q16836* / hydroxyacyl-CoA dehydrogenase*ENSMUSG0000002798413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001753  Enoyl-CoA hydratase/isomerase
 IPR006108  3-hydroxyacyl-CoA dehydrogenase, C-terminal
 IPR006176  3-hydroxyacyl-CoA dehydrogenase, NAD binding
 IPR006180  3-hydroxyacyl-CoA dehydrogenase, conserved site
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR013328  6-phosphogluconate dehydrogenase, domain 2
 IPR018376  Enoyl-CoA hydratase/isomerase, conserved site
 IPR029045  ClpP/crotonase-like domain superfamily
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006475 internal protein amino acid acetylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0006637 acyl-CoA metabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome TAS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003857 3-hydroxyacyl-CoA dehydrogenase activity TAS
 molecular_functionGO:0004165 dodecenoyl-CoA delta-isomerase activity IEA
 molecular_functionGO:0004300 enoyl-CoA hydratase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grid2ho-16J/Grid2ho-16J
Genetic Background: C57BL/6J-Grid2ho-16J/J

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr