ENSMUSG00000027984


Mus musculus

Features
Gene ID: ENSMUSG00000027984
  
Biological name :Hadh
  
Synonyms : Hadh / Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial / Q61425
  
Possible biological names infered from orthology : hydroxyacyl-CoA dehydrogenase / Q16836
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 131233419
Gene end: 131272101
  
Corresponding Affymetrix probe sets: 10502205 (MoGene1.0st)   1436756_x_at (Mouse Genome 430 2.0 Array)   1455972_x_at (Mouse Genome 430 2.0 Array)   1460184_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029610
NCBI entrez gene - 15107     See in Manteia.
MGI - MGI:96009
RefSeq - NM_008212
RefSeq Peptide - NP_032238
swissprot - Q61425
Ensembl - ENSMUSG00000027984
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hadhENSDARG00000030765Danio rerio
 HADHENSGALG00000016124Gallus gallus
 HADHENSG00000138796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ehhadh / Q9DBM2 / Peroxisomal bifunctional enzyme Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase 3-hydroxyacyl-CoA dehydrogenase / Q08426* / enoyl-CoA hydratase and 3-hydroxyacyl CoA deh...ENSMUSG0000002285331
Hadha / Q8BMS1 / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit / P40939* / hydroxyacyl-CoA dehydrogen...ENSMUSG0000002574528


Protein motifs (from Interpro)
Interpro ID Name
 IPR006108  3-hydroxyacyl-CoA dehydrogenase, C-terminal
 IPR006176  3-hydroxyacyl-CoA dehydrogenase, NAD binding
 IPR006180  3-hydroxyacyl-CoA dehydrogenase, conserved site
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR013328  6-phosphogluconate dehydrogenase, domain 2
 IPR022694  3-hydroxyacyl-CoA dehydrogenase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of butanoyl-CoA to acetyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0010028 aciduria "excretion of an acid urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

 MP:0010953 abnormal fatty acid oxidation "anomaly in the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GO:0019395]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027984 Hadh / Q61425 / Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial / Q16836* / hydroxyacyl-CoA dehydrogenase*  / complex






 

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