ENSMUSG00000025745


Mus musculus

Features
Gene ID: ENSMUSG00000025745
  
Biological name :Hadha
  
Synonyms : Hadha / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit / Q8BMS1
  
Possible biological names infered from orthology : hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha / P40939
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 30118304
Gene end: 30155162
  
Corresponding Affymetrix probe sets: 10528929 (MoGene1.0st)   1452173_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143471
Ensembl peptide - ENSMUSP00000120976
NCBI entrez gene - 97212     See in Manteia.
MGI - MGI:2135593
RefSeq - NM_178878
RefSeq Peptide - NP_849209
swissprot - A0A0G2JG90
swissprot - Q8BMS1
Ensembl - ENSMUSG00000025745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hadhaaENSDARG00000057128Danio rerio
 hadhabENSDARG00000060594Danio rerio
 HADHAENSGALG00000016536Gallus gallus
 HADHAENSG00000084754Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ehhadh / Q9DBM2 / Peroxisomal bifunctional enzyme Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase 3-hydroxyacyl-CoA dehydrogenase / Q08426* / enoyl-CoA hydratase and 3-hydroxyacyl CoA deh...ENSMUSG0000002285327
Hadh / Q61425 / Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial / Q16836* / hydroxyacyl-CoA dehydrogenase*ENSMUSG0000002798412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001753  Enoyl-CoA hydratase/isomerase
 IPR006108  3-hydroxyacyl-CoA dehydrogenase, C-terminal
 IPR006176  3-hydroxyacyl-CoA dehydrogenase, NAD binding
 IPR006180  3-hydroxyacyl-CoA dehydrogenase, conserved site
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR012803  Fatty acid oxidation complex, alpha subunit, mitochondrial
 IPR013328  6-phosphogluconate dehydrogenase, domain 2
 IPR018376  Enoyl-CoA hydratase/isomerase, conserved site
 IPR029045  ClpP/crotonase-like domain superfamily
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0000062 fatty-acyl-CoA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0003988 acetyl-CoA C-acyltransferase activity IEA
 molecular_functionGO:0004300 enoyl-CoA hydratase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016508 long-chain-enoyl-CoA hydratase activity IEA
 molecular_functionGO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of CL
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0003978 decreased circulating carnitine level "lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hadhatm1Jib/Hadhatm1Jib
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025745 Hadha / Q8BMS1 / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit / P40939* / hydroxyacyl-CoA dehydrogen...  / complex
 ENSMUSG00000059447 Hadhb / Q99JY0 / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit / P55084* / hydroxyacyl-CoA dehydrogena...  / complex






 

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