ENSMUSG00000059447


Mus musculus

Features
Gene ID: ENSMUSG00000059447
  
Biological name :Hadhb
  
Synonyms : Hadhb / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit / Q99JY0
  
Possible biological names infered from orthology : hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta / P55084
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 30155248
Gene end: 30184593
  
Corresponding Affymetrix probe sets: 10474379 (MoGene1.0st)   10520467 (MoGene1.0st)   1426522_at (Mouse Genome 430 2.0 Array)   1437172_x_at (Mouse Genome 430 2.0 Array)   1442732_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026841
Ensembl peptide - ENSMUSP00000110434
Ensembl peptide - ENSMUSP00000118296
Ensembl peptide - ENSMUSP00000142868
Ensembl peptide - ENSMUSP00000110431
NCBI entrez gene - 231086     See in Manteia.
MGI - MGI:2136381
RefSeq - XM_017320829
RefSeq - NM_001289798
RefSeq - NM_001289799
RefSeq - NM_145558
RefSeq - XM_017320828
RefSeq Peptide - NP_001276727
RefSeq Peptide - NP_001276728
RefSeq Peptide - NP_663533
swissprot - D3YXU1
swissprot - Q99JY0
swissprot - A0A0G2JER1
Ensembl - ENSMUSG00000059447
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HADHBENSDARG00000102055Danio rerio
 HADHBENSGALG00000016555Gallus gallus
 HADHBENSG00000138029Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acaa1b / Q8VCH0 / acetyl-Coenzyme A acyltransferase 1B / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*ENSMUSG0000001065130
Acaa1a / Q921H8 / acetyl-Coenzyme A acyltransferase 1A / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*ENSMUSG0000003613830


Protein motifs (from Interpro)
Interpro ID Name
 IPR002155  Thiolase
 IPR016039  Thiolase-like
 IPR020610  Thiolase, active site
 IPR020613  Thiolase, conserved site
 IPR020615  Thiolase, acyl-enzyme intermediate active site
 IPR020616  Thiolase, N-terminal
 IPR020617  Thiolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex IC
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003988 acetyl-CoA C-acyltransferase activity IMP
 molecular_functionGO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of CL
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025745 Hadha / Q8BMS1 / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit / P40939* / hydroxyacyl-CoA dehydrogen...  / complex
 ENSMUSG00000059447 Hadhb / Q99JY0 / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit / P55084* / hydroxyacyl-CoA dehydrogena...  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr