ENSGALG00000016536


Gallus gallus

Features
Gene ID: ENSGALG00000016536
  
Biological name :HADHA
  
Synonyms : HADHA / hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  
Possible biological names infered from orthology : hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit / P40939 / Q8BMS1
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 105396910
Gene end: 105421148
  
Corresponding Affymetrix probe sets: Gga.3036.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000026633
Ensembl peptide - ENSGALP00000059107
Ensembl peptide - ENSGALP00000057341
NCBI entrez gene - 395929     See in Manteia.
RefSeq - NM_205056
RefSeq - XM_015285092
RefSeq Peptide - NP_990387
swissprot - A0A1L1RK25
swissprot - A0A1D5PWK7
swissprot - F1NI29
Ensembl - ENSGALG00000016536
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hadhaaENSDARG00000057128Danio rerio
 hadhabENSDARG00000060594Danio rerio
 HADHAENSG00000084754Homo sapiens
 HadhaENSMUSG00000025745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EHHADH / enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase / Q08426* / Q9DBM2* / Peroxisomal bifunctional enzyme Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase 3-hydroxyacyl-CoA de...ENSGALG0000000668029
HADH / hydroxyacyl-CoA dehydrogenase / Q16836* / Q61425* / Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial *ENSGALG0000001612412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001753  Enoyl-CoA hydratase/isomerase
 IPR006108  3-hydroxyacyl-CoA dehydrogenase, C-terminal
 IPR006176  3-hydroxyacyl-CoA dehydrogenase, NAD binding
 IPR006180  3-hydroxyacyl-CoA dehydrogenase, conserved site
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR012803  Fatty acid oxidation complex, alpha subunit, mitochondrial
 IPR013328  6-phosphogluconate dehydrogenase, domain 2
 IPR016040  NAD(P)-binding domain
 IPR018376  Enoyl-CoA hydratase/isomerase, conserved site
 IPR029045  ClpP/crotonase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0004300 enoyl-CoA hydratase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of CL
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016536 HADHA / hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha / P40939* / Q8BMS1* / hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzym...  / complex






 

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