ENSMUSG00000022914


Mus musculus

Features
Gene ID: ENSMUSG00000022914
  
Biological name :Brwd1
  
Synonyms : Bromodomain and WD repeat-containing protein 1 / Brwd1 / Q921C3
  
Possible biological names infered from orthology : bromodomain and WD repeat domain containing 1 / Q9NSI6
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 95992092
Gene end: 96082526
  
Corresponding Affymetrix probe sets: 10441115 (MoGene1.0st)   1427322_at (Mouse Genome 430 2.0 Array)   1433955_at (Mouse Genome 430 2.0 Array)   1452321_at (Mouse Genome 430 2.0 Array)   1452322_a_at (Mouse Genome 430 2.0 Array)   1452503_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121141
Ensembl peptide - ENSMUSP00000122457
Ensembl peptide - ENSMUSP00000023631
Ensembl peptide - ENSMUSP00000097101
Ensembl peptide - ENSMUSP00000109458
Ensembl peptide - ENSMUSP00000109460
Ensembl peptide - ENSMUSP00000117066
Ensembl peptide - ENSMUSP00000118327
Ensembl peptide - ENSMUSP00000118423
NCBI entrez gene - 93871     See in Manteia.
MGI - MGI:1890651
RefSeq - XM_006523115
RefSeq - XM_006523114
RefSeq - XM_006523113
RefSeq - XM_011246157
RefSeq - XM_011246156
RefSeq - NM_001103179
RefSeq - NM_145125
RefSeq - NM_176928
RefSeq - XM_017317170
RefSeq - XM_017317169
RefSeq Peptide - NP_795902
RefSeq Peptide - NP_001096649
RefSeq Peptide - NP_660107
swissprot - Q921C3
swissprot - Q8BPZ1
swissprot - F6TDU4
swissprot - E9Q2N1
swissprot - F7D5W0
swissprot - F6X674
swissprot - F6WJH7
Ensembl - ENSMUSG00000022914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brwd1ENSDARG00000074747Danio rerio
 BRWD1ENSGALG00000016065Gallus gallus
 BRWD1ENSG00000185658Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brwd3 / A2AHJ4 / Bromodomain and WD repeat-containing protein 3 / Q6RI45* / bromodomain and WD repeat domain containing 3*ENSMUSG0000006366343
Phip / pleckstrin homology domain interacting protein / Q8WWQ0*ENSMUSG0000003225340


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR018359  Bromodomain, conserved site
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0008360 regulation of cell shape IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Chromatin modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Brwd1Gt(AW0417)Wtsi/Brwd1repro5
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Brwd1Gt(AW0417)Wtsi/Brwd1repro5
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Brwd1Gt(AW0417)Wtsi/Brwd1repro5
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Brwd1Gt(AW0417)Wtsi/Brwd1Gt(AW0417)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Brwd1Gt(AW0417)Wtsi/Brwd1Gt(AW0417)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Brwd1Gt(AW0417)Wtsi/Brwd1Gt(AW0417)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009325 necrospermia "condition in which spermatozoa in seminal fluid are dead or motionless" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032187 Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*  / reaction / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex






 

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