ENSMUSG00000023043


Mus musculus

Features
Gene ID: ENSMUSG00000023043
  
Biological name :Krt18
  
Synonyms : Keratin, type I cytoskeletal 18 / Krt18 / P05784
  
Possible biological names infered from orthology : keratin 18 / P05783
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F2
Gene start: 102028180
Gene end: 102032027
  
Corresponding Affymetrix probe sets: 10427075 (MoGene1.0st)   1448169_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023803
NCBI entrez gene - 16668     See in Manteia.
MGI - MGI:96692
RefSeq - NM_010664
RefSeq Peptide - NP_034794
swissprot - P05784
Ensembl - ENSMUSG00000023043
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt18ENSDARG00000018404Danio rerio
 si:ch211-133j6.3ENSDARG00000058332Danio rerio
 zgc:77517ENSDARG00000028618Danio rerio
 zgc:92380ENSDARG00000041339Danio rerio
 KRT18ENSG00000111057Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt20 / Q9D312 / Keratin, type I cytoskeletal 20 / P35900* / keratin 20*ENSMUSG0000003577541
Krt36 / B1AQ75 / Keratin, type I cuticular Ha6 / O76013* / keratin 36*ENSMUSG0000002091641
Krt31 / Q61765 / Keratin, type I cuticular Ha1 / KRT34* / Q15323* / KRT33A* / KRT33B* / O76011* / O76009* / Q14525* / keratin 31* / keratin 34* / keratin 33A* / keratin 33B*ENSMUSG0000004898138
Krt35 / Q497I4 / Keratin, type I cuticular Ha5 / Q92764* / keratin 35*ENSMUSG0000004801338
Krt34 / Q9D646 / Keratin, type I cuticular Ha4 / KRT31* / Q14525* / O76011* / Q15323* / KRT33A* / KRT33B* / O76009* / keratin 31* / keratin 34* / keratin 33A* / keratin 33B*ENSMUSG0000004348537
Q8K0Y2 / Krt33a / Keratin, type I cuticular Ha3-I / KRT31* / KRT34* / Q14525* / O76011* / Q15323* / KRT33B* / O76009* / keratin 31* / keratin 34* / keratin 33A* / keratin 33B*ENSMUSG0000003559237
Krt39 / Q6IFX4 / Keratin, type I cytoskeletal 39 / Q6A163* / keratin 39*ENSMUSG0000006416536
Q61897 / Krt33b / Keratin, type I cuticular Ha3-II / KRT31* / KRT34* / Q15323* / KRT33A* / O76011* / Q14525* / O76009* / keratin 31* / keratin 34* / keratin 33A* / keratin 33B*ENSMUSG0000005772336
Krt32 / keratin 32 / Q14532*ENSMUSG0000004609536
Krt40 / Q6IFX3 / Keratin, type I cytoskeletal 40 / Q6A162* / keratin 40*ENSMUSG0000005916934


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I
 IPR018039  Intermediate filament protein, conserved site
 IPR027695  Keratin, type I cytoskeletal 18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IGI
 biological_processGO:0043000 Golgi to plasma membrane CFTR protein transport IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045104 intermediate filament cytoskeleton organization IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:0097284 hepatocyte apoptotic process IMP
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005882 intermediate filament ISO
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0034451 centriolar satellite IEA
 cellular_componentGO:0045095 keratin filament IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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