ENSG00000111057


Homo sapiens

Features
Gene ID: ENSG00000111057
  
Biological name :KRT18
  
Synonyms : keratin 18 / KRT18 / P05783
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 52948871
Gene end: 52952901
  
Corresponding Affymetrix probe sets: 201596_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447278
Ensembl peptide - ENSP00000373487
Ensembl peptide - ENSP00000373489
NCBI entrez gene - 3875     See in Manteia.
OMIM - 148070
RefSeq - NM_199187
RefSeq - NM_000224
RefSeq Peptide - NP_000215
RefSeq Peptide - NP_954657
swissprot - P05783
swissprot - A0A024RAY2
swissprot - F8VZY9
Ensembl - ENSG00000111057
  
Related genetic diseases (OMIM): 215600 - Cirrhosis, cryptogenic, 215600
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt18ENSDARG00000018404Danio rerio
 si:ch211-133j6.3ENSDARG00000058332Danio rerio
 zgc:77517ENSDARG00000028618Danio rerio
 zgc:92380ENSDARG00000041339Danio rerio
 Krt18ENSMUSG00000023043Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KRT20 / P35900 / keratin 20ENSG0000017143142
KRT36 / O76013 / keratin 36ENSG0000012633742
KRT35 / Q92764 / keratin 35ENSG0000019707938
KRT32 / Q14532 / keratin 32ENSG0000010875938
KRT33A / O76009 / keratin 33AENSG0000000605937
KRT31 / Q15323 / keratin 31ENSG0000009479637
KRT33B / Q14525 / keratin 33BENSG0000013173837
KRT39 / Q6A163 / keratin 39ENSG0000019685936
KRT34 / O76011 / keratin 34ENSG0000013173735
KRT38 / O76015 / keratin 38ENSG0000017136034
KRT37 / O76014 / keratin 37ENSG0000010841733
KRT40 / Q6A162 / keratin 40ENSG0000020488933


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I
 IPR018039  Intermediate filament protein, conserved site
 IPR027695  Keratin, type I cytoskeletal 18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031424 keratinization TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0043000 Golgi to plasma membrane CFTR protein transport IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045104 intermediate filament cytoskeleton organization IDA
 biological_processGO:0070268 cornification TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005882 intermediate filament TAS
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0034451 centriolar satellite IDA
 cellular_componentGO:0045095 keratin filament IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0097110 scaffold protein binding IPI
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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