ENSMUSG00000023443


Mus musculus

Features
Gene ID: ENSMUSG00000023443
  
Biological name :Esx1
  
Synonyms : Esx1
  
Possible biological names infered from orthology : ESX homeobox 1 / Q8N693
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F1
Gene start: 137115397
Gene end: 137122083
  
Corresponding Affymetrix probe sets: 10606914 (MoGene1.0st)   1420602_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074262
Ensembl peptide - ENSMUSP00000108689
Ensembl peptide - ENSMUSP00000133711
NCBI entrez gene - 13984     See in Manteia.
MGI - MGI:1096388
RefSeq - XM_006528498
RefSeq - NM_007957
RefSeq Peptide - NP_031983
swissprot - A2AG22
swissprot - O88933
swissprot - G3UXJ1
Ensembl - ENSMUSG00000023443
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ESX1ENSG00000123576Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Shox2 / P70390 / short stature homeobox 2 / O60902*ENSMUSG0000002783320
Otp / O09113 / Homeobox protein orthopedia / Q5XKR4* / orthopedia homeobox*ENSMUSG0000002168518
Rhox13 / F6YCR7 / Homeobox protein Rhox13 / Q8NHV9* / RHOXF1* / Rhox homeobox family member 1*ENSMUSG0000005019711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060713 labyrinthine layer morphogenesis IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004920 increased placenta weight "increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011531 abnormal syncytiotrophoblast morphology "any structural anomaly of the multi-nucleated, terminally differentiated syncytial epithelial layer of the placental villi that forms the major nutrient transport surfaces within the labyrinth layer of the rodent placenta" [ISBN-10:0521851653]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012108 increased trophoblast glycogen cell number "greater number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith]
Show

Allelic Composition: Arnttm1Mcs/Arnttm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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