ENSMUSG00000021685


Mus musculus

Features
Gene ID: ENSMUSG00000021685
  
Biological name :Otp
  
Synonyms : Homeobox protein orthopedia / O09113 / Otp
  
Possible biological names infered from orthology : orthopedia homeobox / Q5XKR4
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D1
Gene start: 94875602
Gene end: 94885130
  
Corresponding Affymetrix probe sets: 10406714 (MoGene1.0st)   1422285_at (Mouse Genome 430 2.0 Array)   1444286_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022195
NCBI entrez gene - 18420     See in Manteia.
MGI - MGI:99835
RefSeq - NM_011021
RefSeq - XM_006517567
RefSeq Peptide - NP_035151
swissprot - O09113
Ensembl - ENSMUSG00000021685
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otpaENSDARG00000014201Danio rerio
 otpbENSDARG00000058379Danio rerio
 OTPENSGALG00000026744Gallus gallus
 OTPENSG00000171540Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Shox2 / P70390 / short stature homeobox 2 / O60902*ENSMUSG0000002783323
Esx1 / Q8N693* / ESX homeobox 1*ENSMUSG0000002344321
Rhox13 / F6YCR7 / Homeobox protein Rhox13 / Q8NHV9* / RHOXF1* / Rhox homeobox family member 1*ENSMUSG0000005019712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002052 positive regulation of neuroblast proliferation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021879 forebrain neuron differentiation IMP
 biological_processGO:0021979 hypothalamus cell differentiation IMP
 biological_processGO:0021985 neurohypophysis development IMP
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0004164 abnormal neurophysis morphology "any malfomation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008845 abnormal paraventricular hypothalamic nucleus morphology "any structural anomaly of a group of magnocellular neurons located in the periventricular zone of the anterior half of the hypothalamus" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008846 abnormal supraoptic nucleus morphology "any structural anomaly of a group of cells in the hypothalamus located over the lateral border of the optic tract; neurons produce and transport vasopressin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0009229 abnormal median eminence morphology "any structural anomaly of the raised area at the infundibular region of the hypothalamus where the secretions of the hypothalamic neurons (releasing and inhibiting regulatory hormones) collect before entering the capillary network of hypophyseal portal system" [MESH:A06.688.357.500]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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