ENSDARG00000058379


Danio rerio

Features
Gene ID: ENSDARG00000058379
  
Biological name :otpb
  
Synonyms : orthopedia homeobox b / otpb / Q6DGH9
  
Possible biological names infered from orthology : Homeobox protein orthopedia / O09113 / orthopedia homeobox / OTP / Q5XKR4
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 51615025
Gene end: 51619742
  
Corresponding Affymetrix probe sets: Dr.8118.1.A1_at (Zebrafish Array)   NM_131100_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000148248
Ensembl peptide - ENSDARP00000075692
Ensembl peptide - ENSDARP00000122985
NCBI entrez gene - 30316     See in Manteia.
RefSeq - NM_131100
RefSeq - XM_005165505
RefSeq Peptide - NP_571175
swissprot - Q6DGH9
swissprot - B0S6A5
ZFIN ID - ZDB-GENE-990708-7
Ensembl - ENSDARG00000058379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OTPENSGALG00000026744Gallus gallus
 OTPENSG00000171540Homo sapiens
 OtpENSMUSG00000021685Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
otpa / orthopedia homeobox a / OTP* / Q5XKR4* / orthopedia homeobox*ENSDARG0000001420184
shox2 / short stature homeobox 2 / O60902* / P70390*ENSDARG0000007571321
shox / short stature homeobox / O15266*ENSDARG0000002589121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021767 mammillary body development IGI
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0021884 forebrain neuron development IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus dopaminergic neuron decreased amount , abnormal
hypothalamus has fewer parts of type neurosecretory neuron , abnormal
hypothalamus has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure decreased size , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron decreased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000470 preoptic area preoptic area morphology , abnormal
preoptic area neurosecretory neuron absent , abnormal
Show

 ZFA:0000539 locus coeruleus locus coeruleus adrenergic neuron absent , abnormal
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 ZFA:0000545 medulla oblongata medulla oblongata adrenergic neuron absent , abnormal
Show

 ZFA:0000633 caudal tuberculum caudal tuberculum dopaminergic neuron absent , abnormal
caudal tuberculum dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0005341 medial longitudinal catecholaminergic tract medial longitudinal catecholaminergic tract absent , abnormal
medial longitudinal catecholaminergic tract decreased size , abnormal
Show

 ZFA:0005342 anterior catecholaminergic tract anterior catecholaminergic tract decreased size , abnormal
anterior catecholaminergic tract absent , abnormal
Show

 ZFA:0005344 preopticohypothalamic tract preopticohypothalamic tract absent , abnormal
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 ZFA:0009098 neuroendocrine cell neuroendocrine cell decreased amount , abnormal
neuroendocrine cell poorly differentiated , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell decreased amount , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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