Manteia - Molecule gene

ENSMUSG00000023832

Mus musculus

Features

Gene ID:	ENSMUSG00000023832

Biological name :	Acat2

Synonyms :	Acat2 / acetyl-Coenzyme A acetyltransferase 2 / Q8CAY6

Possible biological names infered from orthology :	acetyl-CoA acetyltransferase 2 / Q9BWD1

Species:	Mus musculus

Chr. number:	17
Strand:	-1
Band:	A1
Gene start:	12942890
Gene end:	12960747

Corresponding Affymetrix probe sets:	10447891 (MoGene1.0st) 1425195_a_at (Mouse Genome 430 2.0 Array) 1435630_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000007005 Ensembl peptide - ENSMUSP00000125066 NCBI entrez gene - 110460 See in Manteia. MGI - MGI:87871 RefSeq - NM_009338 RefSeq Peptide - NP_033364 swissprot - G3XA25 swissprot - Q8CAY6 Ensembl - ENSMUSG00000023832

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
acat2	ENSDARG00000007127	Danio rerio
ACAT2	ENSGALG00000011659	Gallus gallus
ACAT2	ENSG00000120437	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Acat3 / acetyl-Coenzyme A acetyltransferase 3 / ACAT2* / Q9BWD1* / acetyl-CoA acetyltransferase 2*	ENSMUSG00000062480	98
Acat1 / Q8QZT1 / Acetyl-CoA acetyltransferase, mitochondrial / P24752* / acetyl-CoA acetyltransferase 1*	ENSMUSG00000032047	43
Acaa2 / Q8BWT1 / 3-ketoacyl-CoA thiolase, mitochondrial / P42765* / acetyl-CoA acyltransferase 2*	ENSMUSG00000036880	40

Protein motifs (from Interpro)

Interpro ID	Name
IPR002155	Thiolase
IPR016039	Thiolase-like
IPR020610	Thiolase, active site
IPR020613	Thiolase, conserved site
IPR020616	Thiolase, N-terminal
IPR020617	Thiolase, C-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006635	fatty acid beta-oxidation	IBA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0045797	positive regulation of intestinal cholesterol absorption	IDA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005730	nucleolus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0003985	acetyl-CoA C-acetyltransferase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016746	transferase activity, transferring acyl groups	IEA
molecular_function	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	IEA

Pathways (from Reactome)

Pathway description

Cholesterol biosynthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Abcc2^{tm2b(KOMP)Wtsi}/Abcc2^{tm2b(KOMP)Wtsi} Genetic Background: C57BL/6N-Abcc2^{tm2b(KOMP)Wtsi}/H
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu} Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J
MP:0003385	abnormal body wall	"malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcc2^{tm2b(KOMP)Wtsi}/Abcc2^{tm2b(KOMP)Wtsi} Genetic Background: C57BL/6N-Abcc2^{tm2b(KOMP)Wtsi}/H
MP:0003733	abnormal inner nuclear layer morphology	"malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: 4932438A13Rik^{tm1b(EUCOMM)Hmgu}/4932438A13Rik^{tm1b(EUCOMM)Hmgu} Genetic Background: B6N(Cg)-4932438A13Rik^{tm1b(EUCOMM)Hmgu}/J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Abcc2^{tm2b(KOMP)Wtsi}/Abcc2^{tm2b(KOMP)Wtsi} Genetic Background: C57BL/6N-Abcc2^{tm2b(KOMP)Wtsi}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000062480	Acat3 / acetyl-Coenzyme A acetyltransferase 3 / ACAT2* / Q9BWD1* / acetyl-CoA acetyltransferase 2*	/ complex
ENSMUSG00000023832	Acat2 / Q8CAY6 / acetyl-Coenzyme A acetyltransferase 2 / Q9BWD1* / acetyl-CoA acetyltransferase 2*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr