ENSMUSG00000023914


Mus musculus

Features
Gene ID: ENSMUSG00000023914
  
Biological name :Mep1a
  
Synonyms : Mep1a / Meprin A subunit alpha / P28825
  
Possible biological names infered from orthology : Q16819
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B3
Gene start: 43474324
Gene end: 43502812
  
Corresponding Affymetrix probe sets: 10451016 (MoGene1.0st)   1447252_s_at (Mouse Genome 430 2.0 Array)   1450719_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113838
Ensembl peptide - ENSMUSP00000024707
NCBI entrez gene - 17287     See in Manteia.
MGI - MGI:96963
RefSeq - NM_008585
RefSeq - XM_006523751
RefSeq Peptide - NP_032611
swissprot - A0A0R4J043
swissprot - P28825
Ensembl - ENSMUSG00000023914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mep1a.1ENSDARG00000029747Danio rerio
 MEP1AENSGALG00000033033Gallus gallus
 MEP1AENSG00000112818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mep1b / Q61847 / Meprin A subunit beta / Q16820*ENSMUSG0000002431338
Astl / Q6HA09 / Astacin-like metalloendopeptidase / Q6HA08*ENSMUSG0000005046814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000998  MAM domain
 IPR001506  Peptidase M12A
 IPR002083  MATH/TRAF domain
 IPR006026  Peptidase, metallopeptidase
 IPR008294  Meprin alpha/beta subunit
 IPR008974  TRAF-like
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034301  Meprin alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017090 meprin A complex IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0005265 abnormal blood urea nitrogen level "aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0005328 abnormal circulating creatinine level "anomalous blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008640 abnormal circulating interleukin-1 beta level "anomaly in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0011352 proximal convoluted tubule brush border loss "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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