ENSMUSG00000050468


Mus musculus

Features
Gene ID: ENSMUSG00000050468
  
Biological name :Astl
  
Synonyms : Astacin-like metalloendopeptidase / Astl / Q6HA09
  
Possible biological names infered from orthology : Q6HA08
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 127338639
Gene end: 127357651
  
Corresponding Affymetrix probe sets: 10475789 (MoGene1.0st)   1438136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135987
Ensembl peptide - ENSMUSP00000054456
Ensembl peptide - ENSMUSP00000087102
Ensembl peptide - ENSMUSP00000116771
NCBI entrez gene - 215095     See in Manteia.
MGI - MGI:3046414
RefSeq - NM_001291003
RefSeq - NM_172539
RefSeq Peptide - NP_001277932
RefSeq Peptide - NP_766127
swissprot - A2ARG6
swissprot - Q6HA09
Ensembl - ENSMUSG00000050468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 he1.1ENSDARG00000023656Danio rerio
 he1.2ENSDARG00000019122Danio rerio
 he1.3ENSDARG00000022670Danio rerio
 ENSGALG00000043984Gallus gallus
 ASTLENSGALG00000037220Gallus gallus
 ASTLENSG00000188886Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mep1b / Q61847 / Meprin A subunit beta / Q16820*ENSMUSG0000002431326
Mep1a / P28825 / Meprin A subunit alpha / Q16819*ENSMUSG0000002391424


Protein motifs (from Interpro)
Interpro ID Name
 IPR001506  Peptidase M12A
 IPR006026  Peptidase, metallopeptidase
 IPR024079  Metallopeptidase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010954 positive regulation of protein processing IDA
 biological_processGO:0060468 prevention of polyspermy IDA
 biological_processGO:2000360 negative regulation of binding of sperm to zona pellucida IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0060473 cortical granule IDA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070001 aspartic-type peptidase activity IDA
 molecular_functionGO:0070002 glutamic-type peptidase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc26a5tm4.1(cre/ERT2)Jnz/Slc26a5tm4.1(cre/ERT2)Jnz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Astltm1Dean/Astltm1Dean
Genetic Background: involves: 129S6/SvEvTac

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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